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Scaffold-based tissue engineering strategies for soft–hard interface regeneration
Repairing injured tendon or ligament attachments to bones (enthesis) remains costly and challenging. Despite superb surgical management, the disorganized enthesis newly formed after surgery accounts for high recurrence rates after operations. Tissue engineering offers efficient alternatives to promo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847541/ https://www.ncbi.nlm.nih.gov/pubmed/36683751 http://dx.doi.org/10.1093/rb/rbac091 |
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author | Li, Yibo Zhou, Mo Zheng, Wenzhuo Yang, Jianying Jiang, Nan |
author_facet | Li, Yibo Zhou, Mo Zheng, Wenzhuo Yang, Jianying Jiang, Nan |
author_sort | Li, Yibo |
collection | PubMed |
description | Repairing injured tendon or ligament attachments to bones (enthesis) remains costly and challenging. Despite superb surgical management, the disorganized enthesis newly formed after surgery accounts for high recurrence rates after operations. Tissue engineering offers efficient alternatives to promote healing and regeneration of the specialized enthesis tissue. Load-transmitting functions thus can be restored with appropriate biomaterials and engineering strategies. Interestingly, recent studies have focused more on microstructure especially the arrangement of fibers since Rossetti successfully demonstrated the variability of fiber underspecific external force. In this review, we provide an important update on the current strategies for scaffold-based tissue engineering of enthesis when natural structure and properties are equally emphasized. We firstly described compositions, structures and features of natural enthesis with their special mechanical properties highlighted. Stimuli for growth, development and healing of enthesis widely used in popular strategies are systematically summarized. We discuss the fabrication of engineering scaffolds from the aspects of biomaterials, techniques and design strategies and comprehensively evaluate the advantages and disadvantages of each strategy. At last, this review pinpoints the remaining challenges and research directions to make breakthroughs in further studies. |
format | Online Article Text |
id | pubmed-9847541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98475412023-01-20 Scaffold-based tissue engineering strategies for soft–hard interface regeneration Li, Yibo Zhou, Mo Zheng, Wenzhuo Yang, Jianying Jiang, Nan Regen Biomater Review Repairing injured tendon or ligament attachments to bones (enthesis) remains costly and challenging. Despite superb surgical management, the disorganized enthesis newly formed after surgery accounts for high recurrence rates after operations. Tissue engineering offers efficient alternatives to promote healing and regeneration of the specialized enthesis tissue. Load-transmitting functions thus can be restored with appropriate biomaterials and engineering strategies. Interestingly, recent studies have focused more on microstructure especially the arrangement of fibers since Rossetti successfully demonstrated the variability of fiber underspecific external force. In this review, we provide an important update on the current strategies for scaffold-based tissue engineering of enthesis when natural structure and properties are equally emphasized. We firstly described compositions, structures and features of natural enthesis with their special mechanical properties highlighted. Stimuli for growth, development and healing of enthesis widely used in popular strategies are systematically summarized. We discuss the fabrication of engineering scaffolds from the aspects of biomaterials, techniques and design strategies and comprehensively evaluate the advantages and disadvantages of each strategy. At last, this review pinpoints the remaining challenges and research directions to make breakthroughs in further studies. Oxford University Press 2022-11-12 /pmc/articles/PMC9847541/ /pubmed/36683751 http://dx.doi.org/10.1093/rb/rbac091 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Li, Yibo Zhou, Mo Zheng, Wenzhuo Yang, Jianying Jiang, Nan Scaffold-based tissue engineering strategies for soft–hard interface regeneration |
title | Scaffold-based tissue engineering strategies for soft–hard interface regeneration |
title_full | Scaffold-based tissue engineering strategies for soft–hard interface regeneration |
title_fullStr | Scaffold-based tissue engineering strategies for soft–hard interface regeneration |
title_full_unstemmed | Scaffold-based tissue engineering strategies for soft–hard interface regeneration |
title_short | Scaffold-based tissue engineering strategies for soft–hard interface regeneration |
title_sort | scaffold-based tissue engineering strategies for soft–hard interface regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847541/ https://www.ncbi.nlm.nih.gov/pubmed/36683751 http://dx.doi.org/10.1093/rb/rbac091 |
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