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The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke
BACKGROUND AND PURPOSE: The relationship between ionized calcium and prognosis of ischemic stroke is controversial. We aim to determine the relationship of admission ionized calcium levels with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT). METHODS: Consecutive anterior circulatio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847587/ https://www.ncbi.nlm.nih.gov/pubmed/36479811 http://dx.doi.org/10.1002/brb3.2844 |
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author | Qi, Yan‐Li Wu, Qiong Li, Xiao‐Qiu Zhou, Zhong‐He Xia, Cheng Wang, Xin‐Hong Chen, Hui‐Sheng |
author_facet | Qi, Yan‐Li Wu, Qiong Li, Xiao‐Qiu Zhou, Zhong‐He Xia, Cheng Wang, Xin‐Hong Chen, Hui‐Sheng |
author_sort | Qi, Yan‐Li |
collection | PubMed |
description | BACKGROUND AND PURPOSE: The relationship between ionized calcium and prognosis of ischemic stroke is controversial. We aim to determine the relationship of admission ionized calcium levels with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT). METHODS: Consecutive anterior circulation AIS patients treated with recombinant tissue plasminogen activator (rt‐PA) were retrospectively enrolled. According to ionized calcium quartiles, the patients were divided into four groups and clinical data were analyzed between groups. Ionized calcium was entered into logistic regression analysis in two models, separately: model 1, calcium as a continuous variable (per 1‐mmol/L increase), and model 2, calcium as the four‐categorized variable (being collapsed into quartiles: Q1–Q4). Early neurologic improvement (ENI) was defined as improvement of four or more points at 24 h after intravenous rt‐PA, while long‐term good outcome as the modified Rankin Scale (mRS) 0–1 at 90 days. RESULTS: A total of 546 patients met the study criteria (mean age was 63.51 ± 11.26 years and 365 [66.8%] were men). The median admission National Institute of Health Stroke Scale was 9 (range 4 to 15). When not adjusted, in model 1: ionized calcium was related to good outcome (odds ratio [OR] 69.061, 95%CI: 1.638–2911.111, p=0.027), but not ENI (OR 14.097, 95%CI: 0.133–1492.596, p=0.266); in model 2: compared with Q4, while good outcome was less common in Q1 (OR 0.623, 95%CI: 0.388–0.999, p=0.049). After adjusting for confounding factors, calcium in Q2 (OR 0.502, 95%CI: 0.253–0.997, p=0.049) was independently associated with ENI, but no matter as a continuous variable or categorized variable, ionized calcium displayed no association with a good outcome. CONCLUSION: The current results found that ionized calcium might be associated with early neurological improvement, but had no association with 3 months' outcome in anterior circulation AIS patients after IVT. |
format | Online Article Text |
id | pubmed-9847587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98475872023-01-24 The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke Qi, Yan‐Li Wu, Qiong Li, Xiao‐Qiu Zhou, Zhong‐He Xia, Cheng Wang, Xin‐Hong Chen, Hui‐Sheng Brain Behav Original Articles BACKGROUND AND PURPOSE: The relationship between ionized calcium and prognosis of ischemic stroke is controversial. We aim to determine the relationship of admission ionized calcium levels with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT). METHODS: Consecutive anterior circulation AIS patients treated with recombinant tissue plasminogen activator (rt‐PA) were retrospectively enrolled. According to ionized calcium quartiles, the patients were divided into four groups and clinical data were analyzed between groups. Ionized calcium was entered into logistic regression analysis in two models, separately: model 1, calcium as a continuous variable (per 1‐mmol/L increase), and model 2, calcium as the four‐categorized variable (being collapsed into quartiles: Q1–Q4). Early neurologic improvement (ENI) was defined as improvement of four or more points at 24 h after intravenous rt‐PA, while long‐term good outcome as the modified Rankin Scale (mRS) 0–1 at 90 days. RESULTS: A total of 546 patients met the study criteria (mean age was 63.51 ± 11.26 years and 365 [66.8%] were men). The median admission National Institute of Health Stroke Scale was 9 (range 4 to 15). When not adjusted, in model 1: ionized calcium was related to good outcome (odds ratio [OR] 69.061, 95%CI: 1.638–2911.111, p=0.027), but not ENI (OR 14.097, 95%CI: 0.133–1492.596, p=0.266); in model 2: compared with Q4, while good outcome was less common in Q1 (OR 0.623, 95%CI: 0.388–0.999, p=0.049). After adjusting for confounding factors, calcium in Q2 (OR 0.502, 95%CI: 0.253–0.997, p=0.049) was independently associated with ENI, but no matter as a continuous variable or categorized variable, ionized calcium displayed no association with a good outcome. CONCLUSION: The current results found that ionized calcium might be associated with early neurological improvement, but had no association with 3 months' outcome in anterior circulation AIS patients after IVT. John Wiley and Sons Inc. 2022-12-07 /pmc/articles/PMC9847587/ /pubmed/36479811 http://dx.doi.org/10.1002/brb3.2844 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Qi, Yan‐Li Wu, Qiong Li, Xiao‐Qiu Zhou, Zhong‐He Xia, Cheng Wang, Xin‐Hong Chen, Hui‐Sheng The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke |
title | The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke |
title_full | The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke |
title_fullStr | The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke |
title_full_unstemmed | The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke |
title_short | The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke |
title_sort | association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847587/ https://www.ncbi.nlm.nih.gov/pubmed/36479811 http://dx.doi.org/10.1002/brb3.2844 |
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