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Association between prediabetes and cognitive function in Parkinson's disease

INTRODUCTION: It remains largely unknown whether prediabetes is related to cognitive impairment in Parkinson's disease (PD). This study aimed to assess the association between prediabetes and cognitive function in PD patients. METHODS: In this cross‐sectional study, 262 PD patients (age, 69.8 ±...

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Autores principales: Park, Joah, Choi, Seohee, Kim, Ryul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847602/
https://www.ncbi.nlm.nih.gov/pubmed/36448303
http://dx.doi.org/10.1002/brb3.2838
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author Park, Joah
Choi, Seohee
Kim, Ryul
author_facet Park, Joah
Choi, Seohee
Kim, Ryul
author_sort Park, Joah
collection PubMed
description INTRODUCTION: It remains largely unknown whether prediabetes is related to cognitive impairment in Parkinson's disease (PD). This study aimed to assess the association between prediabetes and cognitive function in PD patients. METHODS: In this cross‐sectional study, 262 PD patients (age, 69.8 ± 10.3 years; Hoehn–Yahr stage, 2.3 ± 0.8) were classified into diabetes (glycated hemoglobin [HbA1c] ≥6.5% or previously diagnosed, n = 76), prediabetes (5.7%–6.4%, n = 90), or diabetes free (≤5.6%, n = 96) groups. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) test. RESULTS: Both the diabetes and prediabetes groups had significantly lower MoCA scores (17.0 ± 6.6 and 18.0 ± 6.1, respectively) than the diabetes free group (20.0 ± 5.7), even after adjusting for potential confounders (p = .002 and p = .008, respectively). In the combined group of prediabetes and diabetes free patients, higher HbA1c levels significantly correlated with lower MoCA scores (p = .031). There was a significant interaction of diabetes status with age, but not with the duration of PD, on cognitive function. CONCLUSION: In addition to diabetes, prediabetes may negatively affect cognitive function in PD patients. Further prospective longitudinal studies are necessary to clarify the impact of prediabetes on the cognitive trajectory of these patients.
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spelling pubmed-98476022023-01-24 Association between prediabetes and cognitive function in Parkinson's disease Park, Joah Choi, Seohee Kim, Ryul Brain Behav Brief Reports INTRODUCTION: It remains largely unknown whether prediabetes is related to cognitive impairment in Parkinson's disease (PD). This study aimed to assess the association between prediabetes and cognitive function in PD patients. METHODS: In this cross‐sectional study, 262 PD patients (age, 69.8 ± 10.3 years; Hoehn–Yahr stage, 2.3 ± 0.8) were classified into diabetes (glycated hemoglobin [HbA1c] ≥6.5% or previously diagnosed, n = 76), prediabetes (5.7%–6.4%, n = 90), or diabetes free (≤5.6%, n = 96) groups. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) test. RESULTS: Both the diabetes and prediabetes groups had significantly lower MoCA scores (17.0 ± 6.6 and 18.0 ± 6.1, respectively) than the diabetes free group (20.0 ± 5.7), even after adjusting for potential confounders (p = .002 and p = .008, respectively). In the combined group of prediabetes and diabetes free patients, higher HbA1c levels significantly correlated with lower MoCA scores (p = .031). There was a significant interaction of diabetes status with age, but not with the duration of PD, on cognitive function. CONCLUSION: In addition to diabetes, prediabetes may negatively affect cognitive function in PD patients. Further prospective longitudinal studies are necessary to clarify the impact of prediabetes on the cognitive trajectory of these patients. John Wiley and Sons Inc. 2022-11-30 /pmc/articles/PMC9847602/ /pubmed/36448303 http://dx.doi.org/10.1002/brb3.2838 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Park, Joah
Choi, Seohee
Kim, Ryul
Association between prediabetes and cognitive function in Parkinson's disease
title Association between prediabetes and cognitive function in Parkinson's disease
title_full Association between prediabetes and cognitive function in Parkinson's disease
title_fullStr Association between prediabetes and cognitive function in Parkinson's disease
title_full_unstemmed Association between prediabetes and cognitive function in Parkinson's disease
title_short Association between prediabetes and cognitive function in Parkinson's disease
title_sort association between prediabetes and cognitive function in parkinson's disease
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847602/
https://www.ncbi.nlm.nih.gov/pubmed/36448303
http://dx.doi.org/10.1002/brb3.2838
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