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Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission

Photosensitizers with aggregation-induced emission (AIE PSs) were widely explored in photodynamic therapy. Numerous acceptors but few donors were reported to design AIE PSs. In this study, we developed a new kind of donor that can improve the comprehensive performance of AIE PSs by expanding the π e...

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Detalles Bibliográficos
Autores principales: Wang, Qiang, Li, Chunbin, Song, Yuchen, Shi, Qiankun, Li, Heng, Zhong, Hua, Wang, Jianguo, Hu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847635/
https://www.ncbi.nlm.nih.gov/pubmed/36741529
http://dx.doi.org/10.1039/d2sc05454j
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author Wang, Qiang
Li, Chunbin
Song, Yuchen
Shi, Qiankun
Li, Heng
Zhong, Hua
Wang, Jianguo
Hu, Fang
author_facet Wang, Qiang
Li, Chunbin
Song, Yuchen
Shi, Qiankun
Li, Heng
Zhong, Hua
Wang, Jianguo
Hu, Fang
author_sort Wang, Qiang
collection PubMed
description Photosensitizers with aggregation-induced emission (AIE PSs) were widely explored in photodynamic therapy. Numerous acceptors but few donors were reported to design AIE PSs. In this study, we developed a new kind of donor that can improve the comprehensive performance of AIE PSs by expanding the π extension of aromatic rings at the end of the triphenylamine group through acene enlargement. The absorption and fluorescence peaks of anthryl-substituted AIE PS are red-shifted by 29 nm and 42 nm; the photosensitization efficiency is enhanced by 1.16 times; the AIE factor is 86.1 and the fluorescence quantum yield is 9.3%. We also demonstrated that the anthryl-based AIE PS can image and ablate cancer cells well both in vitro and in vivo. The anthryl-triphenylamine donor provides an excellent option to design donor–acceptor AIE PSs with high comprehensive performance.
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spelling pubmed-98476352023-02-03 Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission Wang, Qiang Li, Chunbin Song, Yuchen Shi, Qiankun Li, Heng Zhong, Hua Wang, Jianguo Hu, Fang Chem Sci Chemistry Photosensitizers with aggregation-induced emission (AIE PSs) were widely explored in photodynamic therapy. Numerous acceptors but few donors were reported to design AIE PSs. In this study, we developed a new kind of donor that can improve the comprehensive performance of AIE PSs by expanding the π extension of aromatic rings at the end of the triphenylamine group through acene enlargement. The absorption and fluorescence peaks of anthryl-substituted AIE PS are red-shifted by 29 nm and 42 nm; the photosensitization efficiency is enhanced by 1.16 times; the AIE factor is 86.1 and the fluorescence quantum yield is 9.3%. We also demonstrated that the anthryl-based AIE PS can image and ablate cancer cells well both in vitro and in vivo. The anthryl-triphenylamine donor provides an excellent option to design donor–acceptor AIE PSs with high comprehensive performance. The Royal Society of Chemistry 2022-12-10 /pmc/articles/PMC9847635/ /pubmed/36741529 http://dx.doi.org/10.1039/d2sc05454j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Qiang
Li, Chunbin
Song, Yuchen
Shi, Qiankun
Li, Heng
Zhong, Hua
Wang, Jianguo
Hu, Fang
Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission
title Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission
title_full Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission
title_fullStr Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission
title_full_unstemmed Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission
title_short Acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission
title_sort acene enlargement for absorption red-shifting and photosensitization enhancement of photosensitizers with aggregation-induced emission
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847635/
https://www.ncbi.nlm.nih.gov/pubmed/36741529
http://dx.doi.org/10.1039/d2sc05454j
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