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Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan

BACKGROUND: Perianal fistula (PF), a complication of Crohn’s disease (CD), affects health-related quality of life (QOL). OBJECTIVE: To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. METHOD: This cross-sectional, observational, web-based questionna...

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Autores principales: Kato, Masafumi, Yoneyama-Hirozane, Mariko, Iwasaki, Katsuhiko, Matsubayashi, Mao, Igarashi, Ataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Routledge 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848226/
https://www.ncbi.nlm.nih.gov/pubmed/36684854
http://dx.doi.org/10.1080/20016689.2023.2166374
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author Kato, Masafumi
Yoneyama-Hirozane, Mariko
Iwasaki, Katsuhiko
Matsubayashi, Mao
Igarashi, Ataru
author_facet Kato, Masafumi
Yoneyama-Hirozane, Mariko
Iwasaki, Katsuhiko
Matsubayashi, Mao
Igarashi, Ataru
author_sort Kato, Masafumi
collection PubMed
description BACKGROUND: Perianal fistula (PF), a complication of Crohn’s disease (CD), affects health-related quality of life (QOL). OBJECTIVE: To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. METHOD: This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies. RESULTS: The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71. CONCLUSION: QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission.
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spelling pubmed-98482262023-01-19 Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan Kato, Masafumi Yoneyama-Hirozane, Mariko Iwasaki, Katsuhiko Matsubayashi, Mao Igarashi, Ataru J Mark Access Health Policy Original Research Article BACKGROUND: Perianal fistula (PF), a complication of Crohn’s disease (CD), affects health-related quality of life (QOL). OBJECTIVE: To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. METHOD: This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies. RESULTS: The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71. CONCLUSION: QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission. Routledge 2023-01-15 /pmc/articles/PMC9848226/ /pubmed/36684854 http://dx.doi.org/10.1080/20016689.2023.2166374 Text en © 2023 Takeda Pharmaceutical Company Limited. Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Kato, Masafumi
Yoneyama-Hirozane, Mariko
Iwasaki, Katsuhiko
Matsubayashi, Mao
Igarashi, Ataru
Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan
title Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan
title_full Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan
title_fullStr Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan
title_full_unstemmed Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan
title_short Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan
title_sort health-related quality of life in health states corresponding to different stages of perianal fistula associated with crohn’s disease: a quantitative evaluation of patients and non-patients in japan
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848226/
https://www.ncbi.nlm.nih.gov/pubmed/36684854
http://dx.doi.org/10.1080/20016689.2023.2166374
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