Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells

Herein, a new series of 2-chloro-N-(5-(2-oxoindolin-3-yl)-4H-pyrazol-3-yl) acetamide derivatives containing 1,3,4-thiadiazole (10a–i) and 4H-1,2,4-triazol-4-amine (11a–r) moiety was designed, synthesised as novel anticancer agents. The antiproliferative activity values indicated that compound 10 b s...

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Detalles Bibliográficos
Autores principales: Zhang, Guanglong, Tang, Zhenhua, Fan, Sili, Li, Chengpeng, Li, Yan, Liu, Weiqin, Long, Xuesha, Zhang, Wenjing, Zhang, Yi, Li, Zhurui, Wang, Zhenchao, Chen, Danping, Ouyang, Guiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848270/
https://www.ncbi.nlm.nih.gov/pubmed/36629428
http://dx.doi.org/10.1080/14756366.2022.2163393

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