Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents

A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors. Compared to Celecoxib, compounds 4b-d and 8d were the most potent derivatives c with a half-maxima...

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Detalles Bibliográficos
Autores principales: Al-Sanea, Mohammad M., Hamdi, Abdelrahman, Brogi, Simone, S. Tawfik, Samar, Othman, Dina I. A., Elshal, Mahmoud, Ur Rahman, Hidayat, Parambi, Della G. T., M. Elbargisy, Rehab, Selim, Samy, Mostafa, Ehab M., Mohamed, Ahmed A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848286/
https://www.ncbi.nlm.nih.gov/pubmed/36633257
http://dx.doi.org/10.1080/14756366.2022.2162511

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