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Epigenetic resetting in the human germ line entails histone modification remodeling

Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic development. We characterize the epigenome of hypomethylated human primordial germ cells (hPGCs) to reveal mechanisms preventing the widespread der...

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Detalles Bibliográficos
Autores principales:	Gruhn, Wolfram H., Tang, Walfred W.C., Dietmann, Sabine, Alves-Lopes, João P., Penfold, Christopher A., Wong, Frederick C. K., Ramakrishna, Navin B., Surani, M. Azim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848478/ https://www.ncbi.nlm.nih.gov/pubmed/36652508 http://dx.doi.org/10.1126/sciadv.ade1257

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