Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation

The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other...

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Detalles Bibliográficos
Autores principales: Karlov, V. D., Pestov, N. B., Shakhparonov, M. I., Korneenko, T. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2023
Materias:
Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848704/
https://www.ncbi.nlm.nih.gov/pubmed/36653584
http://dx.doi.org/10.1134/S1607672922700089
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author Karlov, V. D.
Pestov, N. B.
Shakhparonov, M. I.
Korneenko, T. V.
author_facet Karlov, V. D.
Pestov, N. B.
Shakhparonov, M. I.
Korneenko, T. V.
author_sort Karlov, V. D.
collection PubMed
description The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other methods, indicates the presence of a significant number of indirect interactions between PON2 and EGFR and, consequently, possible regulation of tumor growth with mutant EGFR involving PON2.
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spelling pubmed-98487042023-01-19 Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation Karlov, V. D. Pestov, N. B. Shakhparonov, M. I. Korneenko, T. V. Dokl Biochem Biophys Biochemistry, Biophysics, and Molecular Biology The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other methods, indicates the presence of a significant number of indirect interactions between PON2 and EGFR and, consequently, possible regulation of tumor growth with mutant EGFR involving PON2. Pleiades Publishing 2023-01-18 2023 /pmc/articles/PMC9848704/ /pubmed/36653584 http://dx.doi.org/10.1134/S1607672922700089 Text en © The Author(s) 2023, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2023, Vol. 508, pp. 31–36. © The Author(s), 2023. This article is an open access publication.ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022. © The Author(s), 2022. This article is an open access publication. https://creativecommons.org/licenses/by/4.0/Open Access.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biochemistry, Biophysics, and Molecular Biology
Karlov, V. D.
Pestov, N. B.
Shakhparonov, M. I.
Korneenko, T. V.
Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation
title Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation
title_full Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation
title_fullStr Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation
title_full_unstemmed Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation
title_short Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation
title_sort interactome of paraoxonase pon2 reveals new pathways for tumor growth regulation
topic Biochemistry, Biophysics, and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848704/
https://www.ncbi.nlm.nih.gov/pubmed/36653584
http://dx.doi.org/10.1134/S1607672922700089
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