Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study

In a post‐hoc analysis of the phase 3 BLOCKSTONE study (JapicCTI‐184180), we investigated household transmission of baloxavir‐resistant (PA/I38X) influenza viruses. Using baloxavir resistance rates from prior clinical trials and the rate of influenza transmission observed in the study, the predicted...

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Autores principales: Harding, Joanne, Bernasconi, Corrado, Williams, Sarah, Wildum, Steffen, Kinoshita, Masahiro, Uehara, Takeki, Hurt, Aeron C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849088/
https://www.ncbi.nlm.nih.gov/pubmed/36702798
http://dx.doi.org/10.1111/irv.13079
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author Harding, Joanne
Bernasconi, Corrado
Williams, Sarah
Wildum, Steffen
Kinoshita, Masahiro
Uehara, Takeki
Hurt, Aeron C.
author_facet Harding, Joanne
Bernasconi, Corrado
Williams, Sarah
Wildum, Steffen
Kinoshita, Masahiro
Uehara, Takeki
Hurt, Aeron C.
author_sort Harding, Joanne
collection PubMed
description In a post‐hoc analysis of the phase 3 BLOCKSTONE study (JapicCTI‐184180), we investigated household transmission of baloxavir‐resistant (PA/I38X) influenza viruses. Using baloxavir resistance rates from prior clinical trials and the rate of influenza transmission observed in the study, the predicted number of PA/I38X transmission events was 4.8, assuming wild type and PA/I38X viruses were equally transmissible. However, no PA/I38X viruses were observed. These results suggest a low potential for baloxavir‐resistant influenza virus transmission from treated to untreated individuals, potentially due to reduced viral/transmission fitness for PA/I38X viruses and/or low viral titres at the time when resistant viruses arise.
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spelling pubmed-98490882023-01-24 Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study Harding, Joanne Bernasconi, Corrado Williams, Sarah Wildum, Steffen Kinoshita, Masahiro Uehara, Takeki Hurt, Aeron C. Influenza Other Respir Viruses Short Communications In a post‐hoc analysis of the phase 3 BLOCKSTONE study (JapicCTI‐184180), we investigated household transmission of baloxavir‐resistant (PA/I38X) influenza viruses. Using baloxavir resistance rates from prior clinical trials and the rate of influenza transmission observed in the study, the predicted number of PA/I38X transmission events was 4.8, assuming wild type and PA/I38X viruses were equally transmissible. However, no PA/I38X viruses were observed. These results suggest a low potential for baloxavir‐resistant influenza virus transmission from treated to untreated individuals, potentially due to reduced viral/transmission fitness for PA/I38X viruses and/or low viral titres at the time when resistant viruses arise. John Wiley and Sons Inc. 2023-01-18 /pmc/articles/PMC9849088/ /pubmed/36702798 http://dx.doi.org/10.1111/irv.13079 Text en © 2023 F. Hoffmann‐La Roche Ltd. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Harding, Joanne
Bernasconi, Corrado
Williams, Sarah
Wildum, Steffen
Kinoshita, Masahiro
Uehara, Takeki
Hurt, Aeron C.
Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
title Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
title_full Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
title_fullStr Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
title_full_unstemmed Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
title_short Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
title_sort investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the blockstone study
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849088/
https://www.ncbi.nlm.nih.gov/pubmed/36702798
http://dx.doi.org/10.1111/irv.13079
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