Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

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Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutralizing receptor binding domain (RBD)-specific antibodies with ac...

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Detalles Bibliográficos
Autores principales: Witte, Leander, Baharani, Viren A., Schmidt, Fabian, Wang, Zijun, Cho, Alice, Raspe, Raphael, Guzman-Cardozo, Camila, Muecksch, Frauke, Canis, Marie, Park, Debby J., Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849103/
https://www.ncbi.nlm.nih.gov/pubmed/36653360
http://dx.doi.org/10.1038/s41467-023-35927-0
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