RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2

Cas12a2 is a CRISPR-associated nuclease that performs RNA-guided, sequence-nonspecific degradation of single-stranded RNA, single-stranded DNA and double-stranded DNA following recognition of a complementary RNA target, culminating in abortive infection(1). Here we report structures of Cas12a2 in bi...

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Detalles Bibliográficos
Autores principales: Bravo, Jack P. K., Hallmark, Thomson, Naegle, Bronson, Beisel, Chase L., Jackson, Ryan N., Taylor, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849127/
https://www.ncbi.nlm.nih.gov/pubmed/36599980
http://dx.doi.org/10.1038/s41586-022-05560-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849127/
https://www.ncbi.nlm.nih.gov/pubmed/36599980
http://dx.doi.org/10.1038/s41586-022-05560-w

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