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Inhibition of late sodium current via PI3K/Akt signaling prevents cellular remodeling in tachypacing-induced HL-1 atrial myocytes

An aberrant late sodium current (I(Na,Late)) caused by a mutation in the cardiac sodium channel (Na(v)1.5) has emerged as a contributor to electrical remodeling that causes susceptibility to atrial fibrillation (AF). Although downregulation of phosphoinositide 3-kinase (PI3K)/Akt signaling is associ...

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Detalles Bibliográficos
Autores principales:	Ko, Tae Hee, Jeong, Daun, Yu, Byeongil, Song, Ji Eun, Le, Qui Anh, Woo, Sun-Hee, Choi, Jong-Il
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849166/ https://www.ncbi.nlm.nih.gov/pubmed/36274100 http://dx.doi.org/10.1007/s00424-022-02754-z

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