Cargando…

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation

Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases of the sinonasal tract, pharynx and larynx, are growing health problems yet their genomic similarity is not known. We analyze genome-wide association to eight upper respiratory diseases (61,195 cases) among 26...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saarentaus, Elmo C., Karjalainen, Juha, Rämö, Joel T., Kiiskinen, Tuomo, Havulinna, Aki S., Mehtonen, Juha, Hautakangas, Heidi, Ruotsalainen, Sanni, Tamlander, Max, Mars, Nina, Toppila-Salmi, Sanna, Pirinen, Matti, Kurki, Mitja, Ripatti, Samuli, Daly, Mark, Palotie, Tuula, Mäkitie, Antti, Palotie, Aarno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849224/ https://www.ncbi.nlm.nih.gov/pubmed/36653354 http://dx.doi.org/10.1038/s41467-022-33626-w

Ejemplares similares

Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population
por: Helkkula, Pyry, et al.
Publicado: (2023)

Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
por: Kiiskinen, Tuomo, et al.
Publicado: (2023)

Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants
por: Saarentaus, Elmo Christian, et al.
Publicado: (2021)

Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure
por: Rämö, Joel T., et al.
Publicado: (2023)

Sleep apnoea is a risk factor for severe COVID-19
por: Strausz, Satu, et al.
Publicado: (2021)

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease
por: Helkkula, Pyry, et al.
Publicado: (2021)

Genomic prediction of alcohol-related morbidity and mortality
por: Kiiskinen, Tuomo, et al.
Publicado: (2020)

Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks
por: Dey, Rounak, et al.
Publicado: (2022)

The relative proportion of comorbidities among rhinitis and rhinosinusitis patients and their impact on visit burden
por: Nuutinen, Mikko, et al.
Publicado: (2022)

Polygenic Hyperlipidemias and Coronary Artery Disease Risk
por: Ripatti, Pietari, et al.
Publicado: (2020)

Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes: a longitudinal population-based study in Finland
por: Strausz, Satu, et al.
Publicado: (2018)

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
por: Ruotsalainen, Sanni E., et al.
Publicado: (2022)

Genetic architecture of human plasma lipidome and its link to cardiovascular disease
por: Tabassum, Rubina, et al.
Publicado: (2019)

The relation of severe malocclusion to patients’ mental and behavioral disorders, growth, and speech problems
por: Koskela, Anu, et al.
Publicado: (2020)

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes
por: Tamlander, Max, et al.
Publicado: (2022)

Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers
por: Palomäki, Antti, et al.
Publicado: (2021)

Genetic risk factors have a substantial impact on healthy life years
por: Jukarainen, Sakari, et al.
Publicado: (2022)

From genetic discovery to future personalized health research
por: Palotie, Aarno, et al.
Publicado: (2013)

The role of polygenic risk and susceptibility genes in breast cancer over the course of life
por: Mars, Nina, et al.
Publicado: (2020)

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma
por: Tanigawa, Yosuke, et al.
Publicado: (2020)

Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population‐Ascertained Hyperlipidemias
por: Rämö, Joel T., et al.
Publicado: (2019)

Fine-Scale Genetic Structure in Finland
por: Kerminen, Sini, et al.
Publicado: (2017)

Systematic comparison of family history and polygenic risk across 24 common diseases
por: Mars, Nina, et al.
Publicado: (2022)

Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population
por: Salo, Perttu P., et al.
Publicado: (2015)

High-resolution population-specific recombination rates and their effect on phasing and genotype imputation
por: Hassan, Shabbeer, et al.
Publicado: (2020)

The Contribution of GWAS Loci in Familial Dyslipidemias
por: Ripatti, Pietari, et al.
Publicado: (2016)

A data-driven medication score predicts 10-year mortality among aging adults
por: Häppölä, Paavo, et al.
Publicado: (2020)

Use of electronic health record data mining for heart failure subtyping
por: Vuori, Matti A., et al.
Publicado: (2023)

Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans
por: Borén, Jan, et al.
Publicado: (2020)

Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
por: Kurki, Mitja I., et al.
Publicado: (2019)

Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom
por: Chheda, Himanshu, et al.
Publicado: (2017)

Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses
por: Sánez Tähtisalo, Heini, et al.
Publicado: (2020)

The Cardiovascular Impact and Genetics of Pericardial Adiposity
por: Rämö, Joel T, et al.
Publicado: (2023)

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
por: Ottensmann, Linda, et al.
Publicado: (2023)

Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy
por: Tyrmi, Jaakko S., et al.
Publicado: (2023)

Lipidome‐ and Genome‐Wide Study to Understand Sex Differences in Circulatory Lipids
por: Tabassum, Rubina, et al.
Publicado: (2022)

FINEMAP: efficient variable selection using summary data from genome-wide association studies
por: Benner, Christian, et al.
Publicado: (2016)

Genetic analyses implicate complex links between adult testosterone levels and health and disease
por: Leinonen, Jaakko T., et al.
Publicado: (2023)

Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study
por: Lemmetyinen, Riikka, et al.
Publicado: (2021)

Mono- and biallelic variant effects on disease at biobank scale
por: Heyne, H. O., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fa92lo0kudrpderis1ab2r75f9