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Importance and implications of exosomes in nephrology and urology
Exosomes are extracellular vesicles that are formed by two invaginations of the plasma membrane and can be released by all eukaryotic cells. Because of their bioactive contents, including nucleic acids and proteins, exosomes can activate a variety of functions in their recipient cells. Due to the pl...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849294/ https://www.ncbi.nlm.nih.gov/pubmed/36399151 http://dx.doi.org/10.1007/s00424-022-02771-y |
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author | Mahl, Lina Ollig, Johanna Schweihofer, Verena Wiegand, Lara Torkler, Phillipp Haerteis, Silke Aung, Thiha |
author_facet | Mahl, Lina Ollig, Johanna Schweihofer, Verena Wiegand, Lara Torkler, Phillipp Haerteis, Silke Aung, Thiha |
author_sort | Mahl, Lina |
collection | PubMed |
description | Exosomes are extracellular vesicles that are formed by two invaginations of the plasma membrane and can be released by all eukaryotic cells. Because of their bioactive contents, including nucleic acids and proteins, exosomes can activate a variety of functions in their recipient cells. Due to the plethora of physiological and pathophysiological functions, exosomes have received a lot of attention from researchers over the past few years. However, there is still no consensus regarding isolation and characterization protocols of exosomes and their subtypes. This heterogeneity poses a lot of methodical challenges but also offers new clinical opportunities simultaneously. So far, exosome-based research is still mostly limited to preclinical experiments and early-stage clinical trials since the translation of experimental findings remains difficult. Exosomes could potentially play an important role as future diagnostic and prognostic agents and might also be part of the development of new treatment strategies. Therefore, they have previously been investigated in a variety of nephrological and urological conditions such as acute kidney injury or prostate cancer. |
format | Online Article Text |
id | pubmed-9849294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-98492942023-01-20 Importance and implications of exosomes in nephrology and urology Mahl, Lina Ollig, Johanna Schweihofer, Verena Wiegand, Lara Torkler, Phillipp Haerteis, Silke Aung, Thiha Pflugers Arch Invited Review Exosomes are extracellular vesicles that are formed by two invaginations of the plasma membrane and can be released by all eukaryotic cells. Because of their bioactive contents, including nucleic acids and proteins, exosomes can activate a variety of functions in their recipient cells. Due to the plethora of physiological and pathophysiological functions, exosomes have received a lot of attention from researchers over the past few years. However, there is still no consensus regarding isolation and characterization protocols of exosomes and their subtypes. This heterogeneity poses a lot of methodical challenges but also offers new clinical opportunities simultaneously. So far, exosome-based research is still mostly limited to preclinical experiments and early-stage clinical trials since the translation of experimental findings remains difficult. Exosomes could potentially play an important role as future diagnostic and prognostic agents and might also be part of the development of new treatment strategies. Therefore, they have previously been investigated in a variety of nephrological and urological conditions such as acute kidney injury or prostate cancer. Springer Berlin Heidelberg 2022-11-18 2023 /pmc/articles/PMC9849294/ /pubmed/36399151 http://dx.doi.org/10.1007/s00424-022-02771-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Invited Review Mahl, Lina Ollig, Johanna Schweihofer, Verena Wiegand, Lara Torkler, Phillipp Haerteis, Silke Aung, Thiha Importance and implications of exosomes in nephrology and urology |
title | Importance and implications of exosomes in nephrology and urology |
title_full | Importance and implications of exosomes in nephrology and urology |
title_fullStr | Importance and implications of exosomes in nephrology and urology |
title_full_unstemmed | Importance and implications of exosomes in nephrology and urology |
title_short | Importance and implications of exosomes in nephrology and urology |
title_sort | importance and implications of exosomes in nephrology and urology |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849294/ https://www.ncbi.nlm.nih.gov/pubmed/36399151 http://dx.doi.org/10.1007/s00424-022-02771-y |
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