A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation

INTRODUCTION: The differentiation of B cells into antibody-secreting plasma cells depends on cell division-coupled, epigenetic and other cellular processes that are incompletely understood. METHODS: We have developed a CRISPR/Cas9-based screen that models an early stage of T cell-dependent plasma ce...

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Detalles Bibliográficos
Autores principales: Xiong, Ermeng, Popp, Oliver, Salomon, Claudia, Mertins, Philipp, Kocks, Christine, Rajewsky, Klaus, Chu, Van Trung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849354/
https://www.ncbi.nlm.nih.gov/pubmed/36685499
http://dx.doi.org/10.3389/fimmu.2022.1083119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849354/
https://www.ncbi.nlm.nih.gov/pubmed/36685499
http://dx.doi.org/10.3389/fimmu.2022.1083119

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