Combination of structure-based virtual screening, molecular docking and molecular dynamics approaches for the discovery of anti-prion fibril flavonoids

Prion diseases are a group of rare neurodegenerative diseases caused by the structural conversion of cellular prion into Scrapie prion resulting aggregated fibrils. Therapy of prion diseases has been developed for several decades, especially drug designs based on the structure of prion monomers. Unf...

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Detalles Bibliográficos
Autores principales: Jheng, Cheng-Ping, Lee, Cheng-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849400/
https://www.ncbi.nlm.nih.gov/pubmed/36685276
http://dx.doi.org/10.3389/fmolb.2022.1088733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849400/
https://www.ncbi.nlm.nih.gov/pubmed/36685276
http://dx.doi.org/10.3389/fmolb.2022.1088733

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