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Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

Fibroblast growth factor 21 (FGF21) has pharmaceutical potential against obesity-related metabolic disorders, including non-alcoholic fatty liver disease. Since thermal stability is a desirable factor for therapeutic proteins, we investigated the thermal behavior of human FGF21. FGF21 remained solub...

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Detalles Bibliográficos
Autores principales:	Jung, Ye-Eun, Lee, Kyeong Won, Cho, Jae Hyun, Bae, Da-Woon, Jeong, Bo-Gyeong, Jung, Yeon-Ju, Park, Soo-Bong, An, Young Jun, Kim, Kyungchan, Lee, Ga Seul, Kang, Lin-Woo, Moon, Jeong Hee, Lee, Jung-Hyun, Kim, Eun-Kyoung, Yim, Hyung-Soon, Cha, Sun-Shin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849446/ https://www.ncbi.nlm.nih.gov/pubmed/36653390 http://dx.doi.org/10.1038/s41598-023-27717-x

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