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The relationship between glucose and the liver-alpha cell axis – A systematic review

Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop. The LACA describes how glucagon secretion and pancreatic alpha cell proliferation are stimulated...

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Autores principales: Pixner, Thomas, Stummer, Nathalie, Schneider, Anna Maria, Lukas, Andreas, Gramlinger, Karin, Julian, Valérie, Thivel, David, Mörwald, Katharina, Mangge, Harald, Dalus, Christopher, Aigner, Elmar, Furthner, Dieter, Weghuber, Daniel, Maruszczak, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849557/
https://www.ncbi.nlm.nih.gov/pubmed/36686477
http://dx.doi.org/10.3389/fendo.2022.1061682
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author Pixner, Thomas
Stummer, Nathalie
Schneider, Anna Maria
Lukas, Andreas
Gramlinger, Karin
Julian, Valérie
Thivel, David
Mörwald, Katharina
Mangge, Harald
Dalus, Christopher
Aigner, Elmar
Furthner, Dieter
Weghuber, Daniel
Maruszczak, Katharina
author_facet Pixner, Thomas
Stummer, Nathalie
Schneider, Anna Maria
Lukas, Andreas
Gramlinger, Karin
Julian, Valérie
Thivel, David
Mörwald, Katharina
Mangge, Harald
Dalus, Christopher
Aigner, Elmar
Furthner, Dieter
Weghuber, Daniel
Maruszczak, Katharina
author_sort Pixner, Thomas
collection PubMed
description Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop. The LACA describes how glucagon secretion and pancreatic alpha cell proliferation are stimulated by circulating amino acids. Glucagon in turn leads to an upregulation of amino acid metabolism and ureagenesis in the liver. Several increasingly common diseases (e.g., non-alcoholic fatty liver disease, type 2 diabetes, obesity) disrupt this feedback loop. It is important for clinicians and researchers alike to understand the liver-alpha cell axis and the metabolic sequelae of these diseases. While most of previous studies have focused on fasting concentrations of glucagon and amino acids, there is limited knowledge of their dynamics after glucose administration. The authors of this systematic review applied PRISMA guidelines and conducted PubMed searches to provide results of 8078 articles (screened and if relevant, studied in full). This systematic review aims to provide better insight into the LACA and its mediators (amino acids and glucagon), focusing on the relationship between glucose and the LACA in adult and pediatric subjects.
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spelling pubmed-98495572023-01-20 The relationship between glucose and the liver-alpha cell axis – A systematic review Pixner, Thomas Stummer, Nathalie Schneider, Anna Maria Lukas, Andreas Gramlinger, Karin Julian, Valérie Thivel, David Mörwald, Katharina Mangge, Harald Dalus, Christopher Aigner, Elmar Furthner, Dieter Weghuber, Daniel Maruszczak, Katharina Front Endocrinol (Lausanne) Endocrinology Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop. The LACA describes how glucagon secretion and pancreatic alpha cell proliferation are stimulated by circulating amino acids. Glucagon in turn leads to an upregulation of amino acid metabolism and ureagenesis in the liver. Several increasingly common diseases (e.g., non-alcoholic fatty liver disease, type 2 diabetes, obesity) disrupt this feedback loop. It is important for clinicians and researchers alike to understand the liver-alpha cell axis and the metabolic sequelae of these diseases. While most of previous studies have focused on fasting concentrations of glucagon and amino acids, there is limited knowledge of their dynamics after glucose administration. The authors of this systematic review applied PRISMA guidelines and conducted PubMed searches to provide results of 8078 articles (screened and if relevant, studied in full). This systematic review aims to provide better insight into the LACA and its mediators (amino acids and glucagon), focusing on the relationship between glucose and the LACA in adult and pediatric subjects. Frontiers Media S.A. 2023-01-05 /pmc/articles/PMC9849557/ /pubmed/36686477 http://dx.doi.org/10.3389/fendo.2022.1061682 Text en Copyright © 2023 Pixner, Stummer, Schneider, Lukas, Gramlinger, Julian, Thivel, Mörwald, Mangge, Dalus, Aigner, Furthner, Weghuber and Maruszczak https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Pixner, Thomas
Stummer, Nathalie
Schneider, Anna Maria
Lukas, Andreas
Gramlinger, Karin
Julian, Valérie
Thivel, David
Mörwald, Katharina
Mangge, Harald
Dalus, Christopher
Aigner, Elmar
Furthner, Dieter
Weghuber, Daniel
Maruszczak, Katharina
The relationship between glucose and the liver-alpha cell axis – A systematic review
title The relationship between glucose and the liver-alpha cell axis – A systematic review
title_full The relationship between glucose and the liver-alpha cell axis – A systematic review
title_fullStr The relationship between glucose and the liver-alpha cell axis – A systematic review
title_full_unstemmed The relationship between glucose and the liver-alpha cell axis – A systematic review
title_short The relationship between glucose and the liver-alpha cell axis – A systematic review
title_sort relationship between glucose and the liver-alpha cell axis – a systematic review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849557/
https://www.ncbi.nlm.nih.gov/pubmed/36686477
http://dx.doi.org/10.3389/fendo.2022.1061682
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