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Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors

Among its many molecular targets, the ubiquitous calcium sensor protein calmodulin (CaM) recognizes and regulates the activity of ryanodine receptors type 1 (RyR1) and 2 (RyR2), mainly expressed in skeletal and cardiac muscle, respectively. Such regulation is essential to achieve controlled contract...

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Detalles Bibliográficos
Autores principales:	Dal Cortivo, Giuditta, Marino, Valerio, Bianconi, Silvia, Dell'Orco, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849693/ https://www.ncbi.nlm.nih.gov/pubmed/36685279 http://dx.doi.org/10.3389/fmolb.2022.1100992

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