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A novel insulin delivery system by β cells encapsulated in microcapsules

Introduction: Diabetes is a growing epidemic worldwide and requires effective clinical therapies. In recent years, β-cell transplantation has emerged as a promising treatment for diabetes, and an encapsulation approach has been proposed to ameliorate this treatment. Methods: Microfluidic technology...

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Detalles Bibliográficos
Autores principales: Luo, Zongjie, Dong, Yutong, Yu, Mengyu, Fu, Xiao, Qiu, Yudong, Sun, Xitai, Chu, Xuehui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849738/
https://www.ncbi.nlm.nih.gov/pubmed/36688040
http://dx.doi.org/10.3389/fchem.2022.1104979
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author Luo, Zongjie
Dong, Yutong
Yu, Mengyu
Fu, Xiao
Qiu, Yudong
Sun, Xitai
Chu, Xuehui
author_facet Luo, Zongjie
Dong, Yutong
Yu, Mengyu
Fu, Xiao
Qiu, Yudong
Sun, Xitai
Chu, Xuehui
author_sort Luo, Zongjie
collection PubMed
description Introduction: Diabetes is a growing epidemic worldwide and requires effective clinical therapies. In recent years, β-cell transplantation has emerged as a promising treatment for diabetes, and an encapsulation approach has been proposed to ameliorate this treatment. Methods: Microfluidic technology had been used to generate microcapsules using a porous sodium alginate shell and a core containing β cells. The microcapsules were transplanted into diabetic mice and the therapeutic effect was measured. Results: Porous hydrogel shell allows exchange of small molecules of nutrients while protecting beta cells from immune rejection, while the core ensures high activity of the encapsulated cells. The glucose control effect of the microcapsules were more durable and better than conventional methods. Discussion: We believe that this system, which is composed of biocompatible porous hydrogel shell and enables highly activity of encapsulated β cells, can enhance therapeutic efficacy and has promising clinical applications.
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spelling pubmed-98497382023-01-20 A novel insulin delivery system by β cells encapsulated in microcapsules Luo, Zongjie Dong, Yutong Yu, Mengyu Fu, Xiao Qiu, Yudong Sun, Xitai Chu, Xuehui Front Chem Chemistry Introduction: Diabetes is a growing epidemic worldwide and requires effective clinical therapies. In recent years, β-cell transplantation has emerged as a promising treatment for diabetes, and an encapsulation approach has been proposed to ameliorate this treatment. Methods: Microfluidic technology had been used to generate microcapsules using a porous sodium alginate shell and a core containing β cells. The microcapsules were transplanted into diabetic mice and the therapeutic effect was measured. Results: Porous hydrogel shell allows exchange of small molecules of nutrients while protecting beta cells from immune rejection, while the core ensures high activity of the encapsulated cells. The glucose control effect of the microcapsules were more durable and better than conventional methods. Discussion: We believe that this system, which is composed of biocompatible porous hydrogel shell and enables highly activity of encapsulated β cells, can enhance therapeutic efficacy and has promising clinical applications. Frontiers Media S.A. 2023-01-05 /pmc/articles/PMC9849738/ /pubmed/36688040 http://dx.doi.org/10.3389/fchem.2022.1104979 Text en Copyright © 2023 Luo, Dong, Yu, Fu, Qiu, Sun and Chu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Luo, Zongjie
Dong, Yutong
Yu, Mengyu
Fu, Xiao
Qiu, Yudong
Sun, Xitai
Chu, Xuehui
A novel insulin delivery system by β cells encapsulated in microcapsules
title A novel insulin delivery system by β cells encapsulated in microcapsules
title_full A novel insulin delivery system by β cells encapsulated in microcapsules
title_fullStr A novel insulin delivery system by β cells encapsulated in microcapsules
title_full_unstemmed A novel insulin delivery system by β cells encapsulated in microcapsules
title_short A novel insulin delivery system by β cells encapsulated in microcapsules
title_sort novel insulin delivery system by β cells encapsulated in microcapsules
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849738/
https://www.ncbi.nlm.nih.gov/pubmed/36688040
http://dx.doi.org/10.3389/fchem.2022.1104979
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