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Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study

BACKGROUND: Hematopoietic stem cell transplantation (HSCT), as a mature technology, has significantly improved the survival rate of children. However, there lack efficient scales to assess the quality of life (QoL) of children with HSCT in China, which has important implications in the care of this...

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Autores principales: Wei, Yuting, Zhang, Heng, Qian, Xiaowen, Xue, Yao, Rong, Liucheng, Wang, Yaping, Jiang, Wenjin, Lin, Rufeng, Lu, Shifeng, Zhai, Xiaowen, Fang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849805/
https://www.ncbi.nlm.nih.gov/pubmed/36683816
http://dx.doi.org/10.3389/fped.2022.964261
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author Wei, Yuting
Zhang, Heng
Qian, Xiaowen
Xue, Yao
Rong, Liucheng
Wang, Yaping
Jiang, Wenjin
Lin, Rufeng
Lu, Shifeng
Zhai, Xiaowen
Fang, Yongjun
author_facet Wei, Yuting
Zhang, Heng
Qian, Xiaowen
Xue, Yao
Rong, Liucheng
Wang, Yaping
Jiang, Wenjin
Lin, Rufeng
Lu, Shifeng
Zhai, Xiaowen
Fang, Yongjun
author_sort Wei, Yuting
collection PubMed
description BACKGROUND: Hematopoietic stem cell transplantation (HSCT), as a mature technology, has significantly improved the survival rate of children. However, there lack efficient scales to assess the quality of life (QoL) of children with HSCT in China, which has important implications in the care of this population. This study aimed to translate the original English Pediatric Quality of Life Inventory™ (PedsQL™) Stem Cell Transplant Module into a Chinese mandarin version, and evaluate its reliability. METHODS: Children of ages 2–18 years who had received HSCT at Children's Hospital of Nanjing Medical University and Children's Hospital of Fudan University were recruited. Children or their parents were asked to fill the PedsQL™ 4.0 Generic Core Scales, PedsQL™ Stem Cell Transplant Module, and PedsQL™ Family Information Form. Feasibility was evaluated by completion rate and the percentage of missing items, reliability by the internal consistency and test-retest reliability, and validity by factor analysis and correlation analysis between the scores of total scale and each dimension. RESULTS: A total of 120 children (mean age 6.37, SD = 3.674) and some parents were included. A low percentage of items were missed in returned reports. Cronbach's alpha coefficient reached 0.70 in the majority of dimensions of both child self-report and parent proxy-report. Test-retest reliability was 0.685 in parents' forms and 0.765 in child's forms. Eight factors were extracted, with a cumulative contribution rate of 74.54%. The correlation between PedsQL™ 4.0 and Transplant Module was 0.748 for children self-report and 0.808 for parent proxy-report. CONCLUSIONS: This study provides evidence that the Chinese mandarin version of the PedsQL™ Stem Cell Transplant is feasible, reliable and valid in evaluating the QoL of Chinese children after HSCT.
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spelling pubmed-98498052023-01-20 Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study Wei, Yuting Zhang, Heng Qian, Xiaowen Xue, Yao Rong, Liucheng Wang, Yaping Jiang, Wenjin Lin, Rufeng Lu, Shifeng Zhai, Xiaowen Fang, Yongjun Front Pediatr Pediatrics BACKGROUND: Hematopoietic stem cell transplantation (HSCT), as a mature technology, has significantly improved the survival rate of children. However, there lack efficient scales to assess the quality of life (QoL) of children with HSCT in China, which has important implications in the care of this population. This study aimed to translate the original English Pediatric Quality of Life Inventory™ (PedsQL™) Stem Cell Transplant Module into a Chinese mandarin version, and evaluate its reliability. METHODS: Children of ages 2–18 years who had received HSCT at Children's Hospital of Nanjing Medical University and Children's Hospital of Fudan University were recruited. Children or their parents were asked to fill the PedsQL™ 4.0 Generic Core Scales, PedsQL™ Stem Cell Transplant Module, and PedsQL™ Family Information Form. Feasibility was evaluated by completion rate and the percentage of missing items, reliability by the internal consistency and test-retest reliability, and validity by factor analysis and correlation analysis between the scores of total scale and each dimension. RESULTS: A total of 120 children (mean age 6.37, SD = 3.674) and some parents were included. A low percentage of items were missed in returned reports. Cronbach's alpha coefficient reached 0.70 in the majority of dimensions of both child self-report and parent proxy-report. Test-retest reliability was 0.685 in parents' forms and 0.765 in child's forms. Eight factors were extracted, with a cumulative contribution rate of 74.54%. The correlation between PedsQL™ 4.0 and Transplant Module was 0.748 for children self-report and 0.808 for parent proxy-report. CONCLUSIONS: This study provides evidence that the Chinese mandarin version of the PedsQL™ Stem Cell Transplant is feasible, reliable and valid in evaluating the QoL of Chinese children after HSCT. Frontiers Media S.A. 2023-01-05 /pmc/articles/PMC9849805/ /pubmed/36683816 http://dx.doi.org/10.3389/fped.2022.964261 Text en © 2023 Wei, Zhang, Qian, Xue, Rong, Wang, Jiang, Lin, Lu, Zhai and Fang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Wei, Yuting
Zhang, Heng
Qian, Xiaowen
Xue, Yao
Rong, Liucheng
Wang, Yaping
Jiang, Wenjin
Lin, Rufeng
Lu, Shifeng
Zhai, Xiaowen
Fang, Yongjun
Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study
title Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study
title_full Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study
title_fullStr Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study
title_full_unstemmed Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study
title_short Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and cross-sectional study
title_sort cross-cultural adaptation and validation of the pedsql™ stem cell transplant module in china: a methodological and cross-sectional study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849805/
https://www.ncbi.nlm.nih.gov/pubmed/36683816
http://dx.doi.org/10.3389/fped.2022.964261
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