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Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo
BACKGROUND: Chronic kidney disease (CKD) is a global challenge. CKD prevalence estimation is central to management strategies and prevention. It is necessary to predict end stage kidney disease (ESKD) and, subsequently, the burden for healthcare systems. In this study we characterize CKD stage 3–5 p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849831/ https://www.ncbi.nlm.nih.gov/pubmed/36658506 http://dx.doi.org/10.1186/s12882-023-03056-x |
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author | Kampmann, Jan Dominik Heaf, James Goya Mogensen, Christian Backer Mickley, Hans Wolff, Donna Lykke Brandt, Frans |
author_facet | Kampmann, Jan Dominik Heaf, James Goya Mogensen, Christian Backer Mickley, Hans Wolff, Donna Lykke Brandt, Frans |
author_sort | Kampmann, Jan Dominik |
collection | PubMed |
description | BACKGROUND: Chronic kidney disease (CKD) is a global challenge. CKD prevalence estimation is central to management strategies and prevention. It is necessary to predict end stage kidney disease (ESKD) and, subsequently, the burden for healthcare systems. In this study we characterize CKD stage 3–5 prevalence and incidence in a cohort covering the majority of the Region of Southern Denmark and investigate individuals’ demographic, socioeconomic, and comorbidity status. METHODS: We used data from the Kidney Disease Cohort (KidDiCo) combining laboratory data from Southern Denmark with Danish national databases. Chronic kidney disease was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. RESULTS: The prevalence varied between 4.83 and 4.98% and incidence rate of CKD was 0.49%/year. The median age was 76.4 years. The proportion of individuals with CKD stage 3–5 in the entire population increased consistently with age. The percentage of women in the CKD 3–5 group was higher than in the background population. Diabetes mellitus, hypertension and cardiovascular disease were more prominent in patients with CKD. CKD stage 5 and ESKD were more frequent as incident CKD stages in the 18–49 year olds when compared to older individuals. CKD patients tended to have a lower socioeconomic status. CONCLUSION: Chronic kidney disease stage 3–5 is common, especially in the elderly. Patients with CKD stage 3–5 are predominantly female. The KidDiCo data suggests an association between lower socioeconomic status and prevalence of CKD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-023-03056-x. |
format | Online Article Text |
id | pubmed-9849831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98498312023-01-19 Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo Kampmann, Jan Dominik Heaf, James Goya Mogensen, Christian Backer Mickley, Hans Wolff, Donna Lykke Brandt, Frans BMC Nephrol Research BACKGROUND: Chronic kidney disease (CKD) is a global challenge. CKD prevalence estimation is central to management strategies and prevention. It is necessary to predict end stage kidney disease (ESKD) and, subsequently, the burden for healthcare systems. In this study we characterize CKD stage 3–5 prevalence and incidence in a cohort covering the majority of the Region of Southern Denmark and investigate individuals’ demographic, socioeconomic, and comorbidity status. METHODS: We used data from the Kidney Disease Cohort (KidDiCo) combining laboratory data from Southern Denmark with Danish national databases. Chronic kidney disease was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. RESULTS: The prevalence varied between 4.83 and 4.98% and incidence rate of CKD was 0.49%/year. The median age was 76.4 years. The proportion of individuals with CKD stage 3–5 in the entire population increased consistently with age. The percentage of women in the CKD 3–5 group was higher than in the background population. Diabetes mellitus, hypertension and cardiovascular disease were more prominent in patients with CKD. CKD stage 5 and ESKD were more frequent as incident CKD stages in the 18–49 year olds when compared to older individuals. CKD patients tended to have a lower socioeconomic status. CONCLUSION: Chronic kidney disease stage 3–5 is common, especially in the elderly. Patients with CKD stage 3–5 are predominantly female. The KidDiCo data suggests an association between lower socioeconomic status and prevalence of CKD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-023-03056-x. BioMed Central 2023-01-19 /pmc/articles/PMC9849831/ /pubmed/36658506 http://dx.doi.org/10.1186/s12882-023-03056-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kampmann, Jan Dominik Heaf, James Goya Mogensen, Christian Backer Mickley, Hans Wolff, Donna Lykke Brandt, Frans Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo |
title | Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo |
title_full | Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo |
title_fullStr | Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo |
title_full_unstemmed | Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo |
title_short | Prevalence and incidence of chronic kidney disease stage 3–5 – results from KidDiCo |
title_sort | prevalence and incidence of chronic kidney disease stage 3–5 – results from kiddico |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849831/ https://www.ncbi.nlm.nih.gov/pubmed/36658506 http://dx.doi.org/10.1186/s12882-023-03056-x |
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