Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background

In vivo induction of antigen (Ag)-specific regulatory T cells (Treg) is considered the holy grail of therapeutic strategies for restoring tolerance in autoimmunity. Unfortunately, in the autoimmune disease multiple sclerosis, an effective and durable therapy targeting the diverse repertoire of emerg...

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Detalles Bibliográficos
Autores principales: Keeler, Geoffrey D., Gaddie, Cristina D., Sagadevan, Addelynn S., Senior, Kevin G., Côté, Isabelle, Rechdan, Michaela, Min, Daniel, Mahan, David, Poma, Bianca, Hoffman, Brad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849872/
https://www.ncbi.nlm.nih.gov/pubmed/36700122
http://dx.doi.org/10.1016/j.omtm.2022.12.011

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