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Liquid Chromatography–Mass Spectrometry-Based Qualitative Profiling of mRNA Therapeutic Reagents Using Stable Isotope-Labeled Standards Followed by the Automatic Quantitation Software Ariadne

[Image: see text] mRNA-based medicines are a promising modality for preventing virus-caused illnesses, including COVID-19, and treating various types of cancer and genetic diseases. To develop such medicines, methods to characterize long mRNA molecules are needed for quality control and metabolic an...

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Detalles Bibliográficos
Autores principales:	Nakayama, Hiroshi, Nobe, Yuko, Koike, Masami, Taoka, Masato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850353/ https://www.ncbi.nlm.nih.gov/pubmed/36574727 http://dx.doi.org/10.1021/acs.analchem.2c04323

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