Cargando…

6-Shogaol Exhibits Anti-viral and Anti-inflammatory Activity in COVID-19-Associated Inflammation by Regulating NLRP3 Inflammasomes

[Image: see text] Recent global health concern motivated the exploration of natural medicinal plant resources as an alternative target for treating COVID-19 infection and associated inflammation. In the current study, a phytochemical, 6-shogaol [1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one; 6-SHO] wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kode, Jyoti, Maharana, Jitendra, Dar, Asif Amin, Mukherjee, Shayanti, Gadewal, Nikhil, Sigalapalli, Dilep Kumar, Kumar, Satyanshu, Panda, Debashis, Ghosh, Soumyajit, Keshry, Supriya Suman, Mamidi, Prabhudutta, Chattopadhyay, Soma, Pradhan, Trupti, Kailaje, Vaishali, Inamdar, Sunil, Gujjarwar, Vidula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850479/ https://www.ncbi.nlm.nih.gov/pubmed/36687062 http://dx.doi.org/10.1021/acsomega.2c07138

Ejemplares similares

Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity
por: Tokala, Ramya, et al.
Publicado: (2020)

MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway
por: Mamidi, Prabhudutta, et al.
Publicado: (2021)

DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication
por: Chatterjee, Sanchari, et al.
Publicado: (2022)

Novel huperzine A based NMDA antagonists: insights from molecular docking, ADME/T and molecular dynamics simulation studies
por: Sigalapalli, Dilep Kumar, et al.
Publicado: (2020)

Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
por: Thatikonda, Sowjanya, et al.
Publicado: (2020)

MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo
por: De, Saikat, et al.
Publicado: (2022)

Anti-inflammatory effect and signaling mechanism of 8-shogaol and 10-shogaol in a dextran sodium sulfate-induced colitis mouse model
por: Kim, Ha-Rim, et al.
Publicado: (2023)

Pyrene-appended bipyridine hydrazone ligand as a turn-on sensor for Cu(2+) and its bioimaging application
por: Hossain, Sayed Muktar, et al.
Publicado: (2020)

Versatile β-Catenin Is Crucial for SARS-CoV-2 Infection
por: Chatterjee, Sanchari, et al.
Publicado: (2022)

Selectivity profile comparison for certain γ-butyrolactone and oxazolidinone-based ligands on a sigma 2 receptor over sigma 1: a molecular docking approach
por: Bhandare, Richie R., et al.
Publicado: (2022)

Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review
por: Sanapalli, Bharat Kumar Reddy, et al.
Publicado: (2022)

Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor
por: He, Liangliang, et al.
Publicado: (2018)

Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages
por: Nayak, Tapas K., et al.
Publicado: (2017)

Orally Administered Natural Lipid Nanoparticle-Loaded 6-Shogaol Shapes the Anti-Inflammatory Microbiota and Metabolome
por: Yang, Chunhua, et al.
Publicado: (2021)

The effect of amantadine on an ion channel protein from Chikungunya virus
por: Dey, Debajit, et al.
Publicado: (2019)

A Novel 2006 Indian Outbreak Strain of Chikungunya Virus Exhibits Different Pattern of Infection as Compared to Prototype Strain
por: Kumar, Abhishek, et al.
Publicado: (2014)

Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity
por: Kumar, Sameer, et al.
Publicado: (2018)

Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation
por: Pooladanda, Venkatesh, et al.
Publicado: (2019)

Filamentous temperature sensitive mutant Z: a putative target to combat antibacterial resistance
por: Kifayat, Sumaiya, et al.
Publicado: (2023)

Deciphering the ATP-binding mechanism(s) in NLRP-NACHT 3D models using structural bioinformatics approaches
por: Maharana, Jitendra, et al.
Publicado: (2018)

Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies
por: Kumar, Abhishek, et al.
Publicado: (2021)

P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages
por: Nayak, Tapas Kumar, et al.
Publicado: (2019)

Inhibition of Chikungunya Virus Replication by 1-[(2-Methylbenzimidazol-1-yl) Methyl]-2-Oxo-Indolin-3-ylidene] Amino] Thiourea(MBZM-N-IBT)
por: Mishra, Priyadarsee, et al.
Publicado: (2016)

The possibility of using shogaol for treatment of ulcerative colitis
por: Hassan, Snur MA, et al.
Publicado: (2018)

Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
por: Mak, Kit-Kay, et al.
Publicado: (2023)

Heat Shock Protein 90 Positively Regulates Chikungunya Virus Replication by Stabilizing Viral Non-Structural Protein nsP2 during Infection
por: Das, Indrani, et al.
Publicado: (2014)

Anti-Survival and Pro-Apoptotic Effects of 6-Shogaol on SW872 Human Liposarcoma Cells via Control of the Intrinsic Caspase Pathway, STAT-3, AMPK, and ER Stress
por: Yadav, Anil Kumar, et al.
Publicado: (2020)

Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects
por: Shih, Hung-Cheng, et al.
Publicado: (2014)

6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells and Exhibits Anti-Tumor Activity In Vivo through Endoplasmic Reticulum Stress
por: Hu, Rong, et al.
Publicado: (2012)

6-Shogaol and 10-Shogaol Synergize Curcumin in Ameliorating Proinflammatory Mediators via the Modulation of TLR4/TRAF6/MAPK and NFκB Translocation
por: Zhou, Xian, et al.
Publicado: (2023)

Improved osteoblast function on titanium implant surfaces coated with nanocomposite Apatite–Wollastonite–Chitosan– an experimental in-vitro study
por: Mukherjee, Shayanti, et al.
Publicado: (2022)

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
por: Bischoff-Kont, Iris, et al.
Publicado: (2021)

Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate
por: Zhang, Huiyun, et al.
Publicado: (2019)

Design of Novel Perovskite-Based Polymeric Poly(l-Lactide-Co-Glycolide) Nanofibers with Anti-Microbial Properties for Tissue Engineering
por: Góra, Aleksander, et al.
Publicado: (2020)

TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages
por: Mahish, Chandan, et al.
Publicado: (2023)

Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells
por: Romero-Arias, Angie C., et al.
Publicado: (2019)

6-Shogaol Mitigates Sepsis-Associated Hepatic Injury through Transcriptional Regulation
por: Guo, Xiaoxuan, et al.
Publicado: (2021)

Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives
por: Phaosiri, Chanokbhorn, et al.
Publicado: (2022)

6-shogaol is a potential treatment for Head and Neck Squamous Cell Carcinoma
por: Hsu, Cheng-Ming, et al.
Publicado: (2023)

Validated HPLC method for identification and quantification of p-hydroxy benzoic acid and agnuside in Vitex negundo and Vitex trifolia
por: Shah, Sonal, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_i9brv4sc7uqk6lcq70jv5ef3vk