Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man

We present a patient case of a 73-year-old man with new-onset substernal chest pain and B symptoms, found on computed tomography imaging to have massive mediastinal lymphadenopathy of more than 6 cm. Positron emission tomography imaging revealed fluorodeoxyglucose-avid nodes further extending to the...

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Autores principales: Maniar, Yash M., Meyer, Christian F., Sharp, Michelle, Zambidis, Elias T., Qaysi, Nada A.I, Horne, Alexandra J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850576/
https://www.ncbi.nlm.nih.gov/pubmed/36683654
http://dx.doi.org/10.7326/aimcc.2022.0539
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author Maniar, Yash M.
Meyer, Christian F.
Sharp, Michelle
Zambidis, Elias T.
Qaysi, Nada A.I
Horne, Alexandra J.
author_facet Maniar, Yash M.
Meyer, Christian F.
Sharp, Michelle
Zambidis, Elias T.
Qaysi, Nada A.I
Horne, Alexandra J.
author_sort Maniar, Yash M.
collection PubMed
description We present a patient case of a 73-year-old man with new-onset substernal chest pain and B symptoms, found on computed tomography imaging to have massive mediastinal lymphadenopathy of more than 6 cm. Positron emission tomography imaging revealed fluorodeoxyglucose-avid nodes further extending to the axillary, abdominal, and inguinal regions. After a broad patient work-up for infectious, malignant, and rheumatic causes, he was ultimately diagnosed with Rosai-Dorfman disease, a rare histiocytic neoplasm, by excisional lymph node biopsy.
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spelling pubmed-98505762023-01-19 Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man Maniar, Yash M. Meyer, Christian F. Sharp, Michelle Zambidis, Elias T. Qaysi, Nada A.I Horne, Alexandra J. Ann Intern Med Clin Cases Article We present a patient case of a 73-year-old man with new-onset substernal chest pain and B symptoms, found on computed tomography imaging to have massive mediastinal lymphadenopathy of more than 6 cm. Positron emission tomography imaging revealed fluorodeoxyglucose-avid nodes further extending to the axillary, abdominal, and inguinal regions. After a broad patient work-up for infectious, malignant, and rheumatic causes, he was ultimately diagnosed with Rosai-Dorfman disease, a rare histiocytic neoplasm, by excisional lymph node biopsy. 2022-10 2022-10-18 /pmc/articles/PMC9850576/ /pubmed/36683654 http://dx.doi.org/10.7326/aimcc.2022.0539 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access This is an open access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND), which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. See: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Article
Maniar, Yash M.
Meyer, Christian F.
Sharp, Michelle
Zambidis, Elias T.
Qaysi, Nada A.I
Horne, Alexandra J.
Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man
title Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man
title_full Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man
title_fullStr Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man
title_full_unstemmed Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man
title_short Rosai-Dorfman Disease Presenting as Massive Mediastinal Lymphadenopathy in an Elderly Man
title_sort rosai-dorfman disease presenting as massive mediastinal lymphadenopathy in an elderly man
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850576/
https://www.ncbi.nlm.nih.gov/pubmed/36683654
http://dx.doi.org/10.7326/aimcc.2022.0539
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