Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis

BACKGROUND: Profound resistance to chemotherapy remains a major challenge in achieving better clinical outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). Recent studies indicate that gemcitabine (GEM) resistance is promoted both by pancreatic stellate cells (PSCs) and through increa...

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Detalles Bibliográficos
Autores principales: Amrutkar, Manoj, Berg, Kjersti, Balto, Aina, Skilbrei, Miguel G., Finstadsveen, Anette V., Aasrum, Monica, Gladhaug, Ivar P., Verbeke, Caroline S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850604/
https://www.ncbi.nlm.nih.gov/pubmed/36658582
http://dx.doi.org/10.1186/s12935-023-02852-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850604/
https://www.ncbi.nlm.nih.gov/pubmed/36658582
http://dx.doi.org/10.1186/s12935-023-02852-7

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