Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients

• BF.7 and BQ.1, escaped most neutralizing antibodies isolated from the recovered COVID-19 individuals and vaccine recipients. • Five potent mAbs were identified that showed a broad neutralizing profile to Omicron subvariants and other VOCs. • These broad neutralizing antibodies targeted the RBD of...

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Autores principales: Chen, Jun, Yang, Jing, Chang, Fangfang, Hu, Yabin, Wu, Qian, Teng, Shishan, Liu, Yongchen, Zhang, Jian, He, Rongzhang, Liu, Bo, Zheng, Xingyu, Liu, Ze, Peng, Yanxi, Xie, Zhenhua, Zhang, Yuanfang, Lu, Rui, Pan, Dong, Wang, You, Peng, Liting, Liu, Wenpei, Li, Yi-Ping, Qu, Xiaowang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850840/
https://www.ncbi.nlm.nih.gov/pubmed/36682433
http://dx.doi.org/10.1016/j.virs.2023.01.005
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author Chen, Jun
Yang, Jing
Chang, Fangfang
Hu, Yabin
Wu, Qian
Teng, Shishan
Liu, Yongchen
Zhang, Jian
He, Rongzhang
Liu, Bo
Zheng, Xingyu
Liu, Ze
Peng, Yanxi
Xie, Zhenhua
Zhang, Yuanfang
Lu, Rui
Pan, Dong
Wang, You
Peng, Liting
Liu, Wenpei
Li, Yi-Ping
Qu, Xiaowang
author_facet Chen, Jun
Yang, Jing
Chang, Fangfang
Hu, Yabin
Wu, Qian
Teng, Shishan
Liu, Yongchen
Zhang, Jian
He, Rongzhang
Liu, Bo
Zheng, Xingyu
Liu, Ze
Peng, Yanxi
Xie, Zhenhua
Zhang, Yuanfang
Lu, Rui
Pan, Dong
Wang, You
Peng, Liting
Liu, Wenpei
Li, Yi-Ping
Qu, Xiaowang
author_sort Chen, Jun
collection PubMed
description • BF.7 and BQ.1, escaped most neutralizing antibodies isolated from the recovered COVID-19 individuals and vaccine recipients. • Five potent mAbs were identified that showed a broad neutralizing profile to Omicron subvariants and other VOCs. • These broad neutralizing antibodies targeted the RBD of the spike protein, competing with ACE2 for binding.
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spelling pubmed-98508402023-01-20 Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients Chen, Jun Yang, Jing Chang, Fangfang Hu, Yabin Wu, Qian Teng, Shishan Liu, Yongchen Zhang, Jian He, Rongzhang Liu, Bo Zheng, Xingyu Liu, Ze Peng, Yanxi Xie, Zhenhua Zhang, Yuanfang Lu, Rui Pan, Dong Wang, You Peng, Liting Liu, Wenpei Li, Yi-Ping Qu, Xiaowang Virol Sin Letter • BF.7 and BQ.1, escaped most neutralizing antibodies isolated from the recovered COVID-19 individuals and vaccine recipients. • Five potent mAbs were identified that showed a broad neutralizing profile to Omicron subvariants and other VOCs. • These broad neutralizing antibodies targeted the RBD of the spike protein, competing with ACE2 for binding. Wuhan Institute of Virology, Chinese Academy of Sciences 2023-01-19 /pmc/articles/PMC9850840/ /pubmed/36682433 http://dx.doi.org/10.1016/j.virs.2023.01.005 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Chen, Jun
Yang, Jing
Chang, Fangfang
Hu, Yabin
Wu, Qian
Teng, Shishan
Liu, Yongchen
Zhang, Jian
He, Rongzhang
Liu, Bo
Zheng, Xingyu
Liu, Ze
Peng, Yanxi
Xie, Zhenhua
Zhang, Yuanfang
Lu, Rui
Pan, Dong
Wang, You
Peng, Liting
Liu, Wenpei
Li, Yi-Ping
Qu, Xiaowang
Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients
title Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients
title_full Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients
title_fullStr Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients
title_full_unstemmed Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients
title_short Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients
title_sort identification of broad neutralizing antibodies against omicron subvariants from covid-19 convalescents and vaccine recipients
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850840/
https://www.ncbi.nlm.nih.gov/pubmed/36682433
http://dx.doi.org/10.1016/j.virs.2023.01.005
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