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Chronic lymphocytic leukemia presence impairs antigen-specific CD8(+) T-cell responses through epigenetic reprogramming towards short-lived effectors

T-cell dysregulation in chronic lymphocytic leukemia (CLL) associates with low response rates to autologous T cell-based therapies. How CLL affects antigen-specific T-cell responses remains largely unknown. We investigated (epi)genetic and functional consequences of antigen-specific T-cell responses...

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Detalles Bibliográficos
Autores principales:	Martens, Anne W. J., Kavazović, Inga, Krapić, Mia, Pack, Su Min, Arens, Ramon, Jongejan, Aldo, Moerland, Perry D., Eldering, Eric, van der Windt, Gerritje J. W., Wensveen, Felix M., Peters, Fleur S., Kater, Arnon P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851097/ https://www.ncbi.nlm.nih.gov/pubmed/36658390 http://dx.doi.org/10.1038/s41375-023-01817-z

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