Systemic Delivery of a Dual PI3K/mTOR Inhibitor More Effective than Topical Delivery in Preventing Anal Carcinogenesis in an HPV Transgenic Mouse Model

INTRODUCTION: Anal dysplasia is a growing health concern that over time can result in squamous cell carcinoma (SqCC) of the anus. In this study, we compare a topical versus systemic (oral) administration of LY3023414, a dual PI3K/mTOR inhibitor, to prevent anal carcinogenesis in a Human Papillomavir...

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Detalles Bibliográficos
Autores principales: Gunder, Laura C, Moyer, Tyra H, Ziolkowski, Marissa R, Keating, Margaret K, Leverson, Glen E, Zhang, Wei, Carchman, Evie H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851170/
https://www.ncbi.nlm.nih.gov/pubmed/36683775
http://dx.doi.org/10.26502/jcsct.5079153

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