Cargando…
Vir2Drug: a drug repurposing framework based on protein similarities between pathogens
We draw from the assumption that similarities between pathogens at both pathogen protein and host protein level, may provide the appropriate framework to identify and rank candidate drugs to be used against a specific pathogen. Vir2Drug is a drug repurposing tool that uses network-based approaches t...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851336/ https://www.ncbi.nlm.nih.gov/pubmed/36513376 http://dx.doi.org/10.1093/bib/bbac536 |
_version_ | 1784872373502083072 |
---|---|
author | Minadakis, George Tomazou, Marios Dietis, Nikolas Spyrou, George M |
author_facet | Minadakis, George Tomazou, Marios Dietis, Nikolas Spyrou, George M |
author_sort | Minadakis, George |
collection | PubMed |
description | We draw from the assumption that similarities between pathogens at both pathogen protein and host protein level, may provide the appropriate framework to identify and rank candidate drugs to be used against a specific pathogen. Vir2Drug is a drug repurposing tool that uses network-based approaches to identify and rank candidate drugs for a specific pathogen, combining information obtained from: (a) ranked pathogen-to-pathogen networks based on protein similarities between pathogens, (b) taxonomy distance between pathogens and (c) drugs targeting specific pathogen’s and host proteins. The underlying pathogen networks are used to screen drugs by means of specific methodologies that account for either the host or pathogen’s protein targets. Vir2Drug is a useful and yet informative tool for drug repurposing against known or unknown pathogens especially in periods where the emergence for repurposed drugs plays significant role in handling viral outbreaks, until reaching a vaccine. The web tool is available at: https://bioinformatics.cing.ac.cy/vir2drug, https://vir2drug.cing-big.hpcf.cyi.ac.cy |
format | Online Article Text |
id | pubmed-9851336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98513362023-01-20 Vir2Drug: a drug repurposing framework based on protein similarities between pathogens Minadakis, George Tomazou, Marios Dietis, Nikolas Spyrou, George M Brief Bioinform Problem Solving Protocol We draw from the assumption that similarities between pathogens at both pathogen protein and host protein level, may provide the appropriate framework to identify and rank candidate drugs to be used against a specific pathogen. Vir2Drug is a drug repurposing tool that uses network-based approaches to identify and rank candidate drugs for a specific pathogen, combining information obtained from: (a) ranked pathogen-to-pathogen networks based on protein similarities between pathogens, (b) taxonomy distance between pathogens and (c) drugs targeting specific pathogen’s and host proteins. The underlying pathogen networks are used to screen drugs by means of specific methodologies that account for either the host or pathogen’s protein targets. Vir2Drug is a useful and yet informative tool for drug repurposing against known or unknown pathogens especially in periods where the emergence for repurposed drugs plays significant role in handling viral outbreaks, until reaching a vaccine. The web tool is available at: https://bioinformatics.cing.ac.cy/vir2drug, https://vir2drug.cing-big.hpcf.cyi.ac.cy Oxford University Press 2022-12-13 /pmc/articles/PMC9851336/ /pubmed/36513376 http://dx.doi.org/10.1093/bib/bbac536 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Problem Solving Protocol Minadakis, George Tomazou, Marios Dietis, Nikolas Spyrou, George M Vir2Drug: a drug repurposing framework based on protein similarities between pathogens |
title | Vir2Drug: a drug repurposing framework based on protein similarities between pathogens |
title_full | Vir2Drug: a drug repurposing framework based on protein similarities between pathogens |
title_fullStr | Vir2Drug: a drug repurposing framework based on protein similarities between pathogens |
title_full_unstemmed | Vir2Drug: a drug repurposing framework based on protein similarities between pathogens |
title_short | Vir2Drug: a drug repurposing framework based on protein similarities between pathogens |
title_sort | vir2drug: a drug repurposing framework based on protein similarities between pathogens |
topic | Problem Solving Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851336/ https://www.ncbi.nlm.nih.gov/pubmed/36513376 http://dx.doi.org/10.1093/bib/bbac536 |
work_keys_str_mv | AT minadakisgeorge vir2drugadrugrepurposingframeworkbasedonproteinsimilaritiesbetweenpathogens AT tomazoumarios vir2drugadrugrepurposingframeworkbasedonproteinsimilaritiesbetweenpathogens AT dietisnikolas vir2drugadrugrepurposingframeworkbasedonproteinsimilaritiesbetweenpathogens AT spyrougeorgem vir2drugadrugrepurposingframeworkbasedonproteinsimilaritiesbetweenpathogens |