Habenular Tcf7l2 links nicotine addiction to diabetes

Diabetes is far more prevalent in smokers than non-smokers, but little is known about underlying mechanisms of vulnerability. Here, we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb), where it regulates the function of nicotinic acetylcholine receptors...

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Detalles Bibliográficos
Autores principales: Duncan, Alexander, Heyer, Mary P., Ishikawa, Masago, Caligiuri, Stephanie P. B., Liu, Xin-an, Chen, Zuxin, di Bonaventura, Maria Vittoria, Elayouby, Karim, Ables, Jessica L., Howe, William M., Bali, Purva, Fillinger, Clementine, Williams, Maya, O’Connor, Richard, Wang, Zichen, Lu, Qun, Kamenecka, Theodore M., Ma’ayan, Avi, O’Neill, Heidi C., Ibanez-Tallon, Ines, Geurts, Aron M., Kenny, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851388/
https://www.ncbi.nlm.nih.gov/pubmed/31619789
http://dx.doi.org/10.1038/s41586-019-1653-x

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