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Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
Dopaminergic neurons in the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson’s Disease, with the ventral region degenerating more severely than the dorsal region. Compared with the dorsal neurons, the ventral neurons in the SNc have distinct dendritic morphology, electroph...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851599/ https://www.ncbi.nlm.nih.gov/pubmed/35820645 http://dx.doi.org/10.1016/j.nbd.2022.105815 |
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author | Evans, R.C. |
author_facet | Evans, R.C. |
author_sort | Evans, R.C. |
collection | PubMed |
description | Dopaminergic neurons in the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson’s Disease, with the ventral region degenerating more severely than the dorsal region. Compared with the dorsal neurons, the ventral neurons in the SNc have distinct dendritic morphology, electrophysiological characteristics, and circuit connections with the basal ganglia. These characteristics shape information processing in the ventral SNc and structure the balance of inhibition and disinhibition in the striatonigral circuitry. In this paper, I review foundational studies and recent work comparing the circuitry of the ventral and dorsal SNc neurons and discuss how loss of the ventral neurons early in Parkinson’s Disease could affect the overall balance of inhibition and disinhibition of dopamine signals. |
format | Online Article Text |
id | pubmed-9851599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-98515992023-01-19 Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions Evans, R.C. Neurobiol Dis Article Dopaminergic neurons in the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson’s Disease, with the ventral region degenerating more severely than the dorsal region. Compared with the dorsal neurons, the ventral neurons in the SNc have distinct dendritic morphology, electrophysiological characteristics, and circuit connections with the basal ganglia. These characteristics shape information processing in the ventral SNc and structure the balance of inhibition and disinhibition in the striatonigral circuitry. In this paper, I review foundational studies and recent work comparing the circuitry of the ventral and dorsal SNc neurons and discuss how loss of the ventral neurons early in Parkinson’s Disease could affect the overall balance of inhibition and disinhibition of dopamine signals. 2022-10-01 2022-07-09 /pmc/articles/PMC9851599/ /pubmed/35820645 http://dx.doi.org/10.1016/j.nbd.2022.105815 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Evans, R.C. Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions |
title | Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions |
title_full | Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions |
title_fullStr | Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions |
title_full_unstemmed | Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions |
title_short | Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions |
title_sort | dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851599/ https://www.ncbi.nlm.nih.gov/pubmed/35820645 http://dx.doi.org/10.1016/j.nbd.2022.105815 |
work_keys_str_mv | AT evansrc dendriticinvolvementininhibitionanddisinhibitionofvulnerabledopaminergicneuronsinhealthyandpathologicalconditions |