Cargando…

Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions

Dopaminergic neurons in the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson’s Disease, with the ventral region degenerating more severely than the dorsal region. Compared with the dorsal neurons, the ventral neurons in the SNc have distinct dendritic morphology, electroph...

Descripción completa

Detalles Bibliográficos
Autor principal: Evans, R.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851599/
https://www.ncbi.nlm.nih.gov/pubmed/35820645
http://dx.doi.org/10.1016/j.nbd.2022.105815
_version_ 1784872437843755008
author Evans, R.C.
author_facet Evans, R.C.
author_sort Evans, R.C.
collection PubMed
description Dopaminergic neurons in the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson’s Disease, with the ventral region degenerating more severely than the dorsal region. Compared with the dorsal neurons, the ventral neurons in the SNc have distinct dendritic morphology, electrophysiological characteristics, and circuit connections with the basal ganglia. These characteristics shape information processing in the ventral SNc and structure the balance of inhibition and disinhibition in the striatonigral circuitry. In this paper, I review foundational studies and recent work comparing the circuitry of the ventral and dorsal SNc neurons and discuss how loss of the ventral neurons early in Parkinson’s Disease could affect the overall balance of inhibition and disinhibition of dopamine signals.
format Online
Article
Text
id pubmed-9851599
institution National Center for Biotechnology Information
language English
publishDate 2022
record_format MEDLINE/PubMed
spelling pubmed-98515992023-01-19 Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions Evans, R.C. Neurobiol Dis Article Dopaminergic neurons in the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson’s Disease, with the ventral region degenerating more severely than the dorsal region. Compared with the dorsal neurons, the ventral neurons in the SNc have distinct dendritic morphology, electrophysiological characteristics, and circuit connections with the basal ganglia. These characteristics shape information processing in the ventral SNc and structure the balance of inhibition and disinhibition in the striatonigral circuitry. In this paper, I review foundational studies and recent work comparing the circuitry of the ventral and dorsal SNc neurons and discuss how loss of the ventral neurons early in Parkinson’s Disease could affect the overall balance of inhibition and disinhibition of dopamine signals. 2022-10-01 2022-07-09 /pmc/articles/PMC9851599/ /pubmed/35820645 http://dx.doi.org/10.1016/j.nbd.2022.105815 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Evans, R.C.
Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
title Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
title_full Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
title_fullStr Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
title_full_unstemmed Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
title_short Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
title_sort dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851599/
https://www.ncbi.nlm.nih.gov/pubmed/35820645
http://dx.doi.org/10.1016/j.nbd.2022.105815
work_keys_str_mv AT evansrc dendriticinvolvementininhibitionanddisinhibitionofvulnerabledopaminergicneuronsinhealthyandpathologicalconditions