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Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

Cholesterol synthesis is both energy- and oxygen-intensive, yet relatively little is known of the regulatory effects of hypoxia on pathway enzymes. We previously showed that the rate-limiting and first oxygen-dependent enzyme of the committed cholesterol synthesis pathway, squalene monooxygenase (SM...

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Detalles Bibliográficos
Autores principales:	Coates, Hudson W, Capell-Hattam, Isabelle M, Olzomer, Ellen M, Du, Ximing, Farrell, Rhonda, Yang, Hongyuan, Byrne, Frances L, Brown, Andrew J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851614/ https://www.ncbi.nlm.nih.gov/pubmed/36655986 http://dx.doi.org/10.7554/eLife.82843

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