Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related molecules and pathways, and the in vivo phenotypic rel...

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Detalles Bibliográficos
Autores principales: Jewett, Cayla E, McCurdy, Bailey L, O'Toole, Eileen T, Stemm-Wolf, Alexander J, Given, Katherine S, Lin, Carrie H, Olsen, Valerie, Martin, Whitney, Reinholdt, Laura, Espinosa, Joaquín M, Sullivan, Kelly D, Macklin, Wendy B, Prekeris, Rytis, Pearson, Chad G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851619/
https://www.ncbi.nlm.nih.gov/pubmed/36656118
http://dx.doi.org/10.7554/eLife.78202

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