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Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia
The aim of this study was to measure the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among workers at the Institut Pasteur de Tunis (IPT), a public health laboratory involved in the management of the COVID-19 pandemic in Tunisia, and to identify risk factors for...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851900/ https://www.ncbi.nlm.nih.gov/pubmed/36658402 http://dx.doi.org/10.1007/s00705-022-05636-y |
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author | Kharroubi, Ghassen Cherif, Ines Ghawar, Wissem Dhaouadi, Nawel Yazidi, Rihab Chaabane, Sana Snoussi, Mohamed Ali Salem, Sadok Ben Hammouda, Wafa Ben Hammouda, Sonia Gharbi, Adel Bel Haj Hmida, Nabil Rourou, Samia Dellagi, Koussay Barbouche, Mohamed-Ridha Benabdessalem, Chaouki Ben Ahmed, Melika Bettaieb, Jihène |
author_facet | Kharroubi, Ghassen Cherif, Ines Ghawar, Wissem Dhaouadi, Nawel Yazidi, Rihab Chaabane, Sana Snoussi, Mohamed Ali Salem, Sadok Ben Hammouda, Wafa Ben Hammouda, Sonia Gharbi, Adel Bel Haj Hmida, Nabil Rourou, Samia Dellagi, Koussay Barbouche, Mohamed-Ridha Benabdessalem, Chaouki Ben Ahmed, Melika Bettaieb, Jihène |
author_sort | Kharroubi, Ghassen |
collection | PubMed |
description | The aim of this study was to measure the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among workers at the Institut Pasteur de Tunis (IPT), a public health laboratory involved in the management of the COVID-19 pandemic in Tunisia, and to identify risk factors for infection in this occupational setting. A cross-sectional survey was conducted on IPT workers not vaccinated against coronavirus disease 2019 (COVID-19). Participants completed a questionnaire that included a history of reverse transcription-polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infection. Immunoglobulin G antibodies against the receptor-binding domain of the spike antigen (anti-S-RBD IgG) and the nucleocapsid protein (anti-N IgG) of the SARS-CoV-2 virus were detected by enzyme-linked immunoassay (ELISA). A multivariate analysis was used to identify factors significantly associated with SARS-CoV-2 infection. A total of 428 workers were enrolled in the study. The prevalence of anti-S-RBD and/or anti-N IgG antibodies was 32.9% [28.7–37.4]. The cumulative incidence of SARS-CoV-2 infection (positive serology and/or previous positive RT-PCR test) was 40.0% [35.5–44.9], while the proportion with asymptomatic infection was 32.9%. One-third of the participants with RT-PCR-confirmed infection tested seronegative more than 90 days postinfection. Participants aged over 40 and laborers were more susceptible to infection (adjusted OR [AOR] = 1.65 [1.08–2.51] and AOR = 2.67 [1.45–4.89], respectively), while tobacco smokers had a lower risk of infection (AOR = 0.54 [0.29–0.97]). The SARS-CoV-2 infection rate among IPT workers was not significantly different from that detected concurrently in the general population. Hence, the professional activities conducted in this public health laboratory did not generate additional risk to that incurred outside the institute in day-to-day activities. |
format | Online Article Text |
id | pubmed-9851900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-98519002023-01-20 Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia Kharroubi, Ghassen Cherif, Ines Ghawar, Wissem Dhaouadi, Nawel Yazidi, Rihab Chaabane, Sana Snoussi, Mohamed Ali Salem, Sadok Ben Hammouda, Wafa Ben Hammouda, Sonia Gharbi, Adel Bel Haj Hmida, Nabil Rourou, Samia Dellagi, Koussay Barbouche, Mohamed-Ridha Benabdessalem, Chaouki Ben Ahmed, Melika Bettaieb, Jihène Arch Virol Original Article The aim of this study was to measure the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among workers at the Institut Pasteur de Tunis (IPT), a public health laboratory involved in the management of the COVID-19 pandemic in Tunisia, and to identify risk factors for infection in this occupational setting. A cross-sectional survey was conducted on IPT workers not vaccinated against coronavirus disease 2019 (COVID-19). Participants completed a questionnaire that included a history of reverse transcription-polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infection. Immunoglobulin G antibodies against the receptor-binding domain of the spike antigen (anti-S-RBD IgG) and the nucleocapsid protein (anti-N IgG) of the SARS-CoV-2 virus were detected by enzyme-linked immunoassay (ELISA). A multivariate analysis was used to identify factors significantly associated with SARS-CoV-2 infection. A total of 428 workers were enrolled in the study. The prevalence of anti-S-RBD and/or anti-N IgG antibodies was 32.9% [28.7–37.4]. The cumulative incidence of SARS-CoV-2 infection (positive serology and/or previous positive RT-PCR test) was 40.0% [35.5–44.9], while the proportion with asymptomatic infection was 32.9%. One-third of the participants with RT-PCR-confirmed infection tested seronegative more than 90 days postinfection. Participants aged over 40 and laborers were more susceptible to infection (adjusted OR [AOR] = 1.65 [1.08–2.51] and AOR = 2.67 [1.45–4.89], respectively), while tobacco smokers had a lower risk of infection (AOR = 0.54 [0.29–0.97]). The SARS-CoV-2 infection rate among IPT workers was not significantly different from that detected concurrently in the general population. Hence, the professional activities conducted in this public health laboratory did not generate additional risk to that incurred outside the institute in day-to-day activities. Springer Vienna 2023-01-20 2023 /pmc/articles/PMC9851900/ /pubmed/36658402 http://dx.doi.org/10.1007/s00705-022-05636-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Kharroubi, Ghassen Cherif, Ines Ghawar, Wissem Dhaouadi, Nawel Yazidi, Rihab Chaabane, Sana Snoussi, Mohamed Ali Salem, Sadok Ben Hammouda, Wafa Ben Hammouda, Sonia Gharbi, Adel Bel Haj Hmida, Nabil Rourou, Samia Dellagi, Koussay Barbouche, Mohamed-Ridha Benabdessalem, Chaouki Ben Ahmed, Melika Bettaieb, Jihène Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia |
title | Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia |
title_full | Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia |
title_fullStr | Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia |
title_full_unstemmed | Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia |
title_short | Incidence and risk factors of SARS-CoV-2 infection among workers in a public health laboratory in Tunisia |
title_sort | incidence and risk factors of sars-cov-2 infection among workers in a public health laboratory in tunisia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851900/ https://www.ncbi.nlm.nih.gov/pubmed/36658402 http://dx.doi.org/10.1007/s00705-022-05636-y |
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