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Diagnostic significance of secondary bacteremia in patients with COVID-19

OBJECTIVES: We investigated the occurrence of non-respiratory bacterial and fungal secondary infections, causative organisms, impact on clinical outcomes, and association between the secondary pathogens and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: This wa...

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Autores principales: Nakagawara, Kensuke, Kamata, Hirofumi, Chubachi, Shotaro, Namkoong, Ho, Tanaka, Hiromu, Lee, Ho, Otake, Shiro, Fukushima, Takahiro, Kusumoto, Tatsuya, Morita, Atsuho, Azekawa, Shuhei, Watase, Mayuko, Asakura, Takanori, Masaki, Katsunori, Ishii, Makoto, Endo, Akifumi, Koike, Ryuji, Ishikura, Hiroyasu, Takata, Tohru, Matsushita, Yasushi, Harada, Norihiro, Kokutou, Hiroyuki, Yoshiyama, Takashi, Kataoka, Kensuke, Mutoh, Yoshikazu, Miyawaki, Masayoshi, Ueda, Soichiro, Ono, Hiroshi, Ono, Takuya, Shoko, Tomohisa, Muranaka, Hiroyuki, Kawamura, Kodai, Mori, Nobuaki, Mochimaru, Takao, Fukui, Mototaka, Chihara, Yusuke, Nagasaki, Yoji, Okamoto, Masaki, Amishima, Masaru, Odani, Toshio, Tani, Mayuko, Nishi, Koichi, Shirai, Yuya, Edahiro, Ryuya, Ando, Akira, Hashimoto, Naozumi, Ogura, Shinji, Kitagawa, Yuichiro, Kita, Toshiyuki, Kagaya, Takashi, Kimura, Yasuhiro, Miyazawa, Naoki, Tsuchida, Tomoya, Fujitani, Shigeki, Murakami, Koji, Sano, Hirohito, Sato, Yuki, Tanino, Yoshinori, Otsuki, Ryo, Mashimo, Shuko, Kuramochi, Mizuki, Hosoda, Yasuo, Hasegawa, Yoshinori, Ueda, Tetsuya, Takaku, Yotaro, Ishiguro, Takashi, Fujiwara, Akiko, Kuwahara, Naota, Kitamura, Hideya, Hagiwara, Eri, Nakamori, Yasushi, Saito, Fukuki, Kono, Yuta, Abe, Shinji, Ishii, Tomoo, Ohba, Takehiko, Kusaka, Yu, Watanabe, Hiroko, Masuda, Makoto, Watanabe, Hiroki, Kimizuka, Yoshifumi, Kawana, Akihiko, Kasamatsu, Yu, Hashimoto, Satoru, Okada, Yukinori, Takano, Tomomi, Katayama, Kazuhiko, Ai, Masumi, Kumanogoh, Atsushi, Sato, Toshiro, Tokunaga, Katsushi, Imoto, Seiya, Kitagawa, Yuko, Kimura, Akinori, Miyano, Satoru, Hasegawa, Naoki, Ogawa, Seishi, Kanai, Takanori, Fukunaga, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851919/
https://www.ncbi.nlm.nih.gov/pubmed/36682606
http://dx.doi.org/10.1016/j.jiac.2023.01.006
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author Nakagawara, Kensuke
Kamata, Hirofumi
Chubachi, Shotaro
Namkoong, Ho
Tanaka, Hiromu
Lee, Ho
Otake, Shiro
Fukushima, Takahiro
Kusumoto, Tatsuya
Morita, Atsuho
Azekawa, Shuhei
Watase, Mayuko
Asakura, Takanori
Masaki, Katsunori
Ishii, Makoto
Endo, Akifumi
Koike, Ryuji
Ishikura, Hiroyasu
Takata, Tohru
Matsushita, Yasushi
Harada, Norihiro
Kokutou, Hiroyuki
Yoshiyama, Takashi
Kataoka, Kensuke
Mutoh, Yoshikazu
Miyawaki, Masayoshi
Ueda, Soichiro
Ono, Hiroshi
Ono, Takuya
Shoko, Tomohisa
Muranaka, Hiroyuki
Kawamura, Kodai
Mori, Nobuaki
Mochimaru, Takao
Fukui, Mototaka
Chihara, Yusuke
Nagasaki, Yoji
Okamoto, Masaki
Amishima, Masaru
Odani, Toshio
Tani, Mayuko
Nishi, Koichi
Shirai, Yuya
Edahiro, Ryuya
Ando, Akira
Hashimoto, Naozumi
Ogura, Shinji
Kitagawa, Yuichiro
Kita, Toshiyuki
Kagaya, Takashi
Kimura, Yasuhiro
Miyazawa, Naoki
Tsuchida, Tomoya
Fujitani, Shigeki
Murakami, Koji
Sano, Hirohito
Sato, Yuki
Tanino, Yoshinori
Otsuki, Ryo
Mashimo, Shuko
Kuramochi, Mizuki
Hosoda, Yasuo
Hasegawa, Yoshinori
Ueda, Tetsuya
Takaku, Yotaro
Ishiguro, Takashi
Fujiwara, Akiko
Kuwahara, Naota
Kitamura, Hideya
Hagiwara, Eri
Nakamori, Yasushi
Saito, Fukuki
Kono, Yuta
Abe, Shinji
Ishii, Tomoo
Ohba, Takehiko
Kusaka, Yu
Watanabe, Hiroko
Masuda, Makoto
Watanabe, Hiroki
Kimizuka, Yoshifumi
Kawana, Akihiko
Kasamatsu, Yu
Hashimoto, Satoru
Okada, Yukinori
Takano, Tomomi
Katayama, Kazuhiko
Ai, Masumi
Kumanogoh, Atsushi
Sato, Toshiro
Tokunaga, Katsushi
Imoto, Seiya
Kitagawa, Yuko
Kimura, Akinori
Miyano, Satoru
Hasegawa, Naoki
Ogawa, Seishi
Kanai, Takanori
Fukunaga, Koichi
author_facet Nakagawara, Kensuke
Kamata, Hirofumi
Chubachi, Shotaro
Namkoong, Ho
Tanaka, Hiromu
Lee, Ho
Otake, Shiro
Fukushima, Takahiro
Kusumoto, Tatsuya
Morita, Atsuho
Azekawa, Shuhei
Watase, Mayuko
Asakura, Takanori
Masaki, Katsunori
Ishii, Makoto
Endo, Akifumi
Koike, Ryuji
Ishikura, Hiroyasu
Takata, Tohru
Matsushita, Yasushi
Harada, Norihiro
Kokutou, Hiroyuki
Yoshiyama, Takashi
Kataoka, Kensuke
Mutoh, Yoshikazu
Miyawaki, Masayoshi
Ueda, Soichiro
Ono, Hiroshi
Ono, Takuya
Shoko, Tomohisa
Muranaka, Hiroyuki
Kawamura, Kodai
Mori, Nobuaki
Mochimaru, Takao
Fukui, Mototaka
Chihara, Yusuke
Nagasaki, Yoji
Okamoto, Masaki
Amishima, Masaru
Odani, Toshio
Tani, Mayuko
Nishi, Koichi
Shirai, Yuya
Edahiro, Ryuya
Ando, Akira
Hashimoto, Naozumi
Ogura, Shinji
Kitagawa, Yuichiro
Kita, Toshiyuki
Kagaya, Takashi
Kimura, Yasuhiro
Miyazawa, Naoki
Tsuchida, Tomoya
Fujitani, Shigeki
Murakami, Koji
Sano, Hirohito
Sato, Yuki
Tanino, Yoshinori
Otsuki, Ryo
Mashimo, Shuko
Kuramochi, Mizuki
Hosoda, Yasuo
Hasegawa, Yoshinori
Ueda, Tetsuya
Takaku, Yotaro
Ishiguro, Takashi
Fujiwara, Akiko
Kuwahara, Naota
Kitamura, Hideya
Hagiwara, Eri
Nakamori, Yasushi
Saito, Fukuki
Kono, Yuta
Abe, Shinji
Ishii, Tomoo
Ohba, Takehiko
Kusaka, Yu
Watanabe, Hiroko
Masuda, Makoto
Watanabe, Hiroki
Kimizuka, Yoshifumi
Kawana, Akihiko
Kasamatsu, Yu
Hashimoto, Satoru
Okada, Yukinori
Takano, Tomomi
Katayama, Kazuhiko
Ai, Masumi
Kumanogoh, Atsushi
Sato, Toshiro
Tokunaga, Katsushi
Imoto, Seiya
Kitagawa, Yuko
Kimura, Akinori
Miyano, Satoru
Hasegawa, Naoki
Ogawa, Seishi
Kanai, Takanori
Fukunaga, Koichi
author_sort Nakagawara, Kensuke
collection PubMed
description OBJECTIVES: We investigated the occurrence of non-respiratory bacterial and fungal secondary infections, causative organisms, impact on clinical outcomes, and association between the secondary pathogens and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: This was a retrospective cohort study that included data from inpatients with COVID-19 from multiple centers participating in the Japan COVID-19 Taskforce (April 2020 to May 2021). We obtained demographic, epidemiological, and microbiological data throughout the course of hospitalization and analyzed the cases of COVID-19 complicated by non-respiratory bacterial infections. RESULTS: Of the 1914 patients included, non-respiratory bacterial infections with COVID-19 were diagnosed in 81 patients (4.2%). Of these, 59 (3.1%) were secondary infections. Bacteremia was the most frequent bacterial infection, occurring in 33 cases (55.9%), followed by urinary tract infections in 16 cases (27.1%). Staphylococcus epidermidis was the most common causative organism of bacteremia. Patients with COVID-19 with non-respiratory secondary bacterial infections had significantly higher mortality, and a multivariate logistic regression analysis demonstrated that those with bacteremia (aOdds Ratio = 15.3 [5.97–39.1]) were at higher risk of death. Multivariate logistic regression analysis showed that age, male sex, use of steroids to treat COVID-19, and intensive care unit admission increased the risk for nosocomial bacteremia. CONCLUSIONS: Secondary bacteremia is an important complication that may lead to poor prognosis in cases with COVID-19. An appropriate medical management strategy must be established, especially for patients with concomitant predisposing factors.
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spelling pubmed-98519192023-01-20 Diagnostic significance of secondary bacteremia in patients with COVID-19 Nakagawara, Kensuke Kamata, Hirofumi Chubachi, Shotaro Namkoong, Ho Tanaka, Hiromu Lee, Ho Otake, Shiro Fukushima, Takahiro Kusumoto, Tatsuya Morita, Atsuho Azekawa, Shuhei Watase, Mayuko Asakura, Takanori Masaki, Katsunori Ishii, Makoto Endo, Akifumi Koike, Ryuji Ishikura, Hiroyasu Takata, Tohru Matsushita, Yasushi Harada, Norihiro Kokutou, Hiroyuki Yoshiyama, Takashi Kataoka, Kensuke Mutoh, Yoshikazu Miyawaki, Masayoshi Ueda, Soichiro Ono, Hiroshi Ono, Takuya Shoko, Tomohisa Muranaka, Hiroyuki Kawamura, Kodai Mori, Nobuaki Mochimaru, Takao Fukui, Mototaka Chihara, Yusuke Nagasaki, Yoji Okamoto, Masaki Amishima, Masaru Odani, Toshio Tani, Mayuko Nishi, Koichi Shirai, Yuya Edahiro, Ryuya Ando, Akira Hashimoto, Naozumi Ogura, Shinji Kitagawa, Yuichiro Kita, Toshiyuki Kagaya, Takashi Kimura, Yasuhiro Miyazawa, Naoki Tsuchida, Tomoya Fujitani, Shigeki Murakami, Koji Sano, Hirohito Sato, Yuki Tanino, Yoshinori Otsuki, Ryo Mashimo, Shuko Kuramochi, Mizuki Hosoda, Yasuo Hasegawa, Yoshinori Ueda, Tetsuya Takaku, Yotaro Ishiguro, Takashi Fujiwara, Akiko Kuwahara, Naota Kitamura, Hideya Hagiwara, Eri Nakamori, Yasushi Saito, Fukuki Kono, Yuta Abe, Shinji Ishii, Tomoo Ohba, Takehiko Kusaka, Yu Watanabe, Hiroko Masuda, Makoto Watanabe, Hiroki Kimizuka, Yoshifumi Kawana, Akihiko Kasamatsu, Yu Hashimoto, Satoru Okada, Yukinori Takano, Tomomi Katayama, Kazuhiko Ai, Masumi Kumanogoh, Atsushi Sato, Toshiro Tokunaga, Katsushi Imoto, Seiya Kitagawa, Yuko Kimura, Akinori Miyano, Satoru Hasegawa, Naoki Ogawa, Seishi Kanai, Takanori Fukunaga, Koichi J Infect Chemother Note OBJECTIVES: We investigated the occurrence of non-respiratory bacterial and fungal secondary infections, causative organisms, impact on clinical outcomes, and association between the secondary pathogens and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: This was a retrospective cohort study that included data from inpatients with COVID-19 from multiple centers participating in the Japan COVID-19 Taskforce (April 2020 to May 2021). We obtained demographic, epidemiological, and microbiological data throughout the course of hospitalization and analyzed the cases of COVID-19 complicated by non-respiratory bacterial infections. RESULTS: Of the 1914 patients included, non-respiratory bacterial infections with COVID-19 were diagnosed in 81 patients (4.2%). Of these, 59 (3.1%) were secondary infections. Bacteremia was the most frequent bacterial infection, occurring in 33 cases (55.9%), followed by urinary tract infections in 16 cases (27.1%). Staphylococcus epidermidis was the most common causative organism of bacteremia. Patients with COVID-19 with non-respiratory secondary bacterial infections had significantly higher mortality, and a multivariate logistic regression analysis demonstrated that those with bacteremia (aOdds Ratio = 15.3 [5.97–39.1]) were at higher risk of death. Multivariate logistic regression analysis showed that age, male sex, use of steroids to treat COVID-19, and intensive care unit admission increased the risk for nosocomial bacteremia. CONCLUSIONS: Secondary bacteremia is an important complication that may lead to poor prognosis in cases with COVID-19. An appropriate medical management strategy must be established, especially for patients with concomitant predisposing factors. Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. 2023-04 2023-01-20 /pmc/articles/PMC9851919/ /pubmed/36682606 http://dx.doi.org/10.1016/j.jiac.2023.01.006 Text en © 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Note
Nakagawara, Kensuke
Kamata, Hirofumi
Chubachi, Shotaro
Namkoong, Ho
Tanaka, Hiromu
Lee, Ho
Otake, Shiro
Fukushima, Takahiro
Kusumoto, Tatsuya
Morita, Atsuho
Azekawa, Shuhei
Watase, Mayuko
Asakura, Takanori
Masaki, Katsunori
Ishii, Makoto
Endo, Akifumi
Koike, Ryuji
Ishikura, Hiroyasu
Takata, Tohru
Matsushita, Yasushi
Harada, Norihiro
Kokutou, Hiroyuki
Yoshiyama, Takashi
Kataoka, Kensuke
Mutoh, Yoshikazu
Miyawaki, Masayoshi
Ueda, Soichiro
Ono, Hiroshi
Ono, Takuya
Shoko, Tomohisa
Muranaka, Hiroyuki
Kawamura, Kodai
Mori, Nobuaki
Mochimaru, Takao
Fukui, Mototaka
Chihara, Yusuke
Nagasaki, Yoji
Okamoto, Masaki
Amishima, Masaru
Odani, Toshio
Tani, Mayuko
Nishi, Koichi
Shirai, Yuya
Edahiro, Ryuya
Ando, Akira
Hashimoto, Naozumi
Ogura, Shinji
Kitagawa, Yuichiro
Kita, Toshiyuki
Kagaya, Takashi
Kimura, Yasuhiro
Miyazawa, Naoki
Tsuchida, Tomoya
Fujitani, Shigeki
Murakami, Koji
Sano, Hirohito
Sato, Yuki
Tanino, Yoshinori
Otsuki, Ryo
Mashimo, Shuko
Kuramochi, Mizuki
Hosoda, Yasuo
Hasegawa, Yoshinori
Ueda, Tetsuya
Takaku, Yotaro
Ishiguro, Takashi
Fujiwara, Akiko
Kuwahara, Naota
Kitamura, Hideya
Hagiwara, Eri
Nakamori, Yasushi
Saito, Fukuki
Kono, Yuta
Abe, Shinji
Ishii, Tomoo
Ohba, Takehiko
Kusaka, Yu
Watanabe, Hiroko
Masuda, Makoto
Watanabe, Hiroki
Kimizuka, Yoshifumi
Kawana, Akihiko
Kasamatsu, Yu
Hashimoto, Satoru
Okada, Yukinori
Takano, Tomomi
Katayama, Kazuhiko
Ai, Masumi
Kumanogoh, Atsushi
Sato, Toshiro
Tokunaga, Katsushi
Imoto, Seiya
Kitagawa, Yuko
Kimura, Akinori
Miyano, Satoru
Hasegawa, Naoki
Ogawa, Seishi
Kanai, Takanori
Fukunaga, Koichi
Diagnostic significance of secondary bacteremia in patients with COVID-19
title Diagnostic significance of secondary bacteremia in patients with COVID-19
title_full Diagnostic significance of secondary bacteremia in patients with COVID-19
title_fullStr Diagnostic significance of secondary bacteremia in patients with COVID-19
title_full_unstemmed Diagnostic significance of secondary bacteremia in patients with COVID-19
title_short Diagnostic significance of secondary bacteremia in patients with COVID-19
title_sort diagnostic significance of secondary bacteremia in patients with covid-19
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851919/
https://www.ncbi.nlm.nih.gov/pubmed/36682606
http://dx.doi.org/10.1016/j.jiac.2023.01.006
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