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Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma
OBJECTIVES: Parasagittal meningioma resection is prone to postoperative complications and tumor recurrence because the tumor invades the superior sagittal sinus. This study aimed to clarify the incidence of perioperative complications and the recurrence of superior sagittal paranasal meningiomas and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852056/ https://www.ncbi.nlm.nih.gov/pubmed/36684270 http://dx.doi.org/10.3389/fsurg.2022.1023021 |
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author | Chen, Wei-Wei Wang, Yong Hu, Yang-Chun Zhao, Yuan-Li |
author_facet | Chen, Wei-Wei Wang, Yong Hu, Yang-Chun Zhao, Yuan-Li |
author_sort | Chen, Wei-Wei |
collection | PubMed |
description | OBJECTIVES: Parasagittal meningioma resection is prone to postoperative complications and tumor recurrence because the tumor invades the superior sagittal sinus. This study aimed to clarify the incidence of perioperative complications and the recurrence of superior sagittal paranasal meningiomas and explored potential predictors in this context. METHODS: The study retrospectively reviewed the clinical, imaging, and follow-up data of parasagittal meningiomas among patients who underwent microsurgical resection in the authors' institution from January 2008 to December 2017. Univariate and multivariate logistic regression analyses were conducted to explore independent predictors of perioperative complications and tumor recurrence. RESULTS: A total of 212 parasagittal meningioma patients were included in this study. The incidence of perioperative complications was 23.6% (50/212), and perioperative death occurred in 6 (2.8%) patients. In univariate and multivariate logistic regression analyses of perioperative complications, peritumoral edema ≥1 cm (odds ratio [OR] 2.163, 95% confidence interval [CI] 1.057–4.428, P = 0.035) and the Sindou invasion Class V-VI(OR0.018, 95% CI 1.248–11.064, P = 0.018) were independent predictors. After an average of 83 (39–154) months of clinical follow up among the living 206 patients, 22 (10.7%) patients showed tumor recurrence. In univariate and multivariate logistic regression analyses of tumor recurrence, the Sindou invasion Class III-IV (OR 5.539, 95%CI 1.469–20.884, P = 0.011) and the Sindou invasion Class V-VI (OR 9.144, 95%CI 2.215–37.757, P = 0.002) were independent predictors. CONCLUSIONS: Peritumoral edema ≥1 cm and the Sindou invasion Class V-VI were the independent predictors of perioperative complications, and the Sindou invasion Class III-IV and the Sindou invasion Class V-VI were the independent predictors of tumor recurrence. The part of the parasagittal meningioma involving the sinus wall should be actively removed to the largest degree possible to reduce the recurrence rate. |
format | Online Article Text |
id | pubmed-9852056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98520562023-01-21 Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma Chen, Wei-Wei Wang, Yong Hu, Yang-Chun Zhao, Yuan-Li Front Surg Surgery OBJECTIVES: Parasagittal meningioma resection is prone to postoperative complications and tumor recurrence because the tumor invades the superior sagittal sinus. This study aimed to clarify the incidence of perioperative complications and the recurrence of superior sagittal paranasal meningiomas and explored potential predictors in this context. METHODS: The study retrospectively reviewed the clinical, imaging, and follow-up data of parasagittal meningiomas among patients who underwent microsurgical resection in the authors' institution from January 2008 to December 2017. Univariate and multivariate logistic regression analyses were conducted to explore independent predictors of perioperative complications and tumor recurrence. RESULTS: A total of 212 parasagittal meningioma patients were included in this study. The incidence of perioperative complications was 23.6% (50/212), and perioperative death occurred in 6 (2.8%) patients. In univariate and multivariate logistic regression analyses of perioperative complications, peritumoral edema ≥1 cm (odds ratio [OR] 2.163, 95% confidence interval [CI] 1.057–4.428, P = 0.035) and the Sindou invasion Class V-VI(OR0.018, 95% CI 1.248–11.064, P = 0.018) were independent predictors. After an average of 83 (39–154) months of clinical follow up among the living 206 patients, 22 (10.7%) patients showed tumor recurrence. In univariate and multivariate logistic regression analyses of tumor recurrence, the Sindou invasion Class III-IV (OR 5.539, 95%CI 1.469–20.884, P = 0.011) and the Sindou invasion Class V-VI (OR 9.144, 95%CI 2.215–37.757, P = 0.002) were independent predictors. CONCLUSIONS: Peritumoral edema ≥1 cm and the Sindou invasion Class V-VI were the independent predictors of perioperative complications, and the Sindou invasion Class III-IV and the Sindou invasion Class V-VI were the independent predictors of tumor recurrence. The part of the parasagittal meningioma involving the sinus wall should be actively removed to the largest degree possible to reduce the recurrence rate. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9852056/ /pubmed/36684270 http://dx.doi.org/10.3389/fsurg.2022.1023021 Text en © 2023 Chen, Wang, Hu and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Chen, Wei-Wei Wang, Yong Hu, Yang-Chun Zhao, Yuan-Li Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma |
title | Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma |
title_full | Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma |
title_fullStr | Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma |
title_full_unstemmed | Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma |
title_short | Analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma |
title_sort | analysis of the common complications and recurrence-related factors of superior parasagittal sinus meningioma |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852056/ https://www.ncbi.nlm.nih.gov/pubmed/36684270 http://dx.doi.org/10.3389/fsurg.2022.1023021 |
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