Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer

A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2–20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. Thi...

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Autores principales: Talavera-Urquijo, Eider, Davies, Andrew R., Wijnhoven, Bas P. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852102/
https://www.ncbi.nlm.nih.gov/pubmed/35842570
http://dx.doi.org/10.1007/s13304-022-01315-4
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author Talavera-Urquijo, Eider
Davies, Andrew R.
Wijnhoven, Bas P. L.
author_facet Talavera-Urquijo, Eider
Davies, Andrew R.
Wijnhoven, Bas P. L.
author_sort Talavera-Urquijo, Eider
collection PubMed
description A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2–20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.
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spelling pubmed-98521022023-01-21 Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer Talavera-Urquijo, Eider Davies, Andrew R. Wijnhoven, Bas P. L. Updates Surg Review Article A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2–20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear. Springer International Publishing 2022-07-16 2023 /pmc/articles/PMC9852102/ /pubmed/35842570 http://dx.doi.org/10.1007/s13304-022-01315-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Talavera-Urquijo, Eider
Davies, Andrew R.
Wijnhoven, Bas P. L.
Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer
title Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer
title_full Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer
title_fullStr Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer
title_full_unstemmed Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer
title_short Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer
title_sort prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852102/
https://www.ncbi.nlm.nih.gov/pubmed/35842570
http://dx.doi.org/10.1007/s13304-022-01315-4
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