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Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants

To validate the pressure–time index of the inspiratory muscles as a non-invasive index of inspiratory muscle function in spontaneously breathing infants by comparing it against the gold-standard pressure–time index of the diaphragm. Prospective observational cohort study of consecutive infants breat...

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Autores principales: Dassios, Theodore, Vervenioti, Aggeliki, Tzifas, Sotirios, Fouzas, Sotirios, Dimitriou, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852111/
https://www.ncbi.nlm.nih.gov/pubmed/35674857
http://dx.doi.org/10.1007/s10877-022-00882-6
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author Dassios, Theodore
Vervenioti, Aggeliki
Tzifas, Sotirios
Fouzas, Sotirios
Dimitriou, Gabriel
author_facet Dassios, Theodore
Vervenioti, Aggeliki
Tzifas, Sotirios
Fouzas, Sotirios
Dimitriou, Gabriel
author_sort Dassios, Theodore
collection PubMed
description To validate the pressure–time index of the inspiratory muscles as a non-invasive index of inspiratory muscle function in spontaneously breathing infants by comparing it against the gold-standard pressure–time index of the diaphragm. Prospective observational cohort study of consecutive infants breathing unsupported in room air in a tertiary neonatal intensive care unit, studied prior to discharge from neonatal care. The invasive pressure–time index of the diaphragm was calculated using a transdiaphragmatic dual-pressure catheter that measured transdiaphragmatic pressure by subtraction of the oesophageal from the gastric pressure. The non-invasive pressure–time index of the inspiratory muscles was calculated using pressure measurements at the level of the mouth via a differential pressure transducer connected to a face mask. Both indices were calculated as the product of the ratio of the mean inspiratory pressure divided by the maximum inspiratory pressure and the ratio of the inspiratory time divided by the total time of a respiratory cycle. One hundred and thirty infants (79 male) were included with a mean (SD) gestational age of 35.2 (3.2) weeks, studied at a median (IQR) postnatal age of 9 (6–20) days. The mean (SD) pressure–time index of the diaphragm was 0.063 (0.019) and the mean (SD) pressure–time index of the inspiratory muscles was 0.065 (0.023). The correlation coefficient for the two indices was 0.509 (p < 0.001). The mean (SD) absolute difference between the pressure–time index of the inspiratory muscles and pressure–time index of the diaphragm was 0.002 (0.021). In convalescent infants, the non-invasive pressure–time index of the inspiratory muscles had a moderate degree of correlation with the invasively derived pressure time index of the diaphragm measured with a transdiaphragmatic catheter.
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spelling pubmed-98521112023-01-21 Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants Dassios, Theodore Vervenioti, Aggeliki Tzifas, Sotirios Fouzas, Sotirios Dimitriou, Gabriel J Clin Monit Comput Original Research To validate the pressure–time index of the inspiratory muscles as a non-invasive index of inspiratory muscle function in spontaneously breathing infants by comparing it against the gold-standard pressure–time index of the diaphragm. Prospective observational cohort study of consecutive infants breathing unsupported in room air in a tertiary neonatal intensive care unit, studied prior to discharge from neonatal care. The invasive pressure–time index of the diaphragm was calculated using a transdiaphragmatic dual-pressure catheter that measured transdiaphragmatic pressure by subtraction of the oesophageal from the gastric pressure. The non-invasive pressure–time index of the inspiratory muscles was calculated using pressure measurements at the level of the mouth via a differential pressure transducer connected to a face mask. Both indices were calculated as the product of the ratio of the mean inspiratory pressure divided by the maximum inspiratory pressure and the ratio of the inspiratory time divided by the total time of a respiratory cycle. One hundred and thirty infants (79 male) were included with a mean (SD) gestational age of 35.2 (3.2) weeks, studied at a median (IQR) postnatal age of 9 (6–20) days. The mean (SD) pressure–time index of the diaphragm was 0.063 (0.019) and the mean (SD) pressure–time index of the inspiratory muscles was 0.065 (0.023). The correlation coefficient for the two indices was 0.509 (p < 0.001). The mean (SD) absolute difference between the pressure–time index of the inspiratory muscles and pressure–time index of the diaphragm was 0.002 (0.021). In convalescent infants, the non-invasive pressure–time index of the inspiratory muscles had a moderate degree of correlation with the invasively derived pressure time index of the diaphragm measured with a transdiaphragmatic catheter. Springer Netherlands 2022-06-08 2023 /pmc/articles/PMC9852111/ /pubmed/35674857 http://dx.doi.org/10.1007/s10877-022-00882-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Dassios, Theodore
Vervenioti, Aggeliki
Tzifas, Sotirios
Fouzas, Sotirios
Dimitriou, Gabriel
Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants
title Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants
title_full Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants
title_fullStr Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants
title_full_unstemmed Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants
title_short Validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants
title_sort validation of a non-invasive pressure–time index of the inspiratory muscles in spontaneously breathing newborn infants
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852111/
https://www.ncbi.nlm.nih.gov/pubmed/35674857
http://dx.doi.org/10.1007/s10877-022-00882-6
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