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(123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation

PURPOSE: Heart failure (HF) is a primary cause of morbidity and mortality worldwide, with significant impact on life quality and extensive healthcare costs. Assessment of myocardial sympathetic innervation function plays a central role in prognosis assessment in HF patients. The aim of this review i...

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Autores principales: Gargiulo, Paola, Acampa, Wanda, Asile, Gaetano, Abbate, Vincenza, Nardi, Ermanno, Marzano, Federica, Assante, Roberta, Nappi, Carmela, Parlati, Antonio Luca Maria, Basile, Christian, Dellegrottaglie, Santo, Paolillo, Stefania, Cuocolo, Alberto, Perrone-Filardi, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852124/
https://www.ncbi.nlm.nih.gov/pubmed/36071220
http://dx.doi.org/10.1007/s00259-022-05941-3
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author Gargiulo, Paola
Acampa, Wanda
Asile, Gaetano
Abbate, Vincenza
Nardi, Ermanno
Marzano, Federica
Assante, Roberta
Nappi, Carmela
Parlati, Antonio Luca Maria
Basile, Christian
Dellegrottaglie, Santo
Paolillo, Stefania
Cuocolo, Alberto
Perrone-Filardi, Pasquale
author_facet Gargiulo, Paola
Acampa, Wanda
Asile, Gaetano
Abbate, Vincenza
Nardi, Ermanno
Marzano, Federica
Assante, Roberta
Nappi, Carmela
Parlati, Antonio Luca Maria
Basile, Christian
Dellegrottaglie, Santo
Paolillo, Stefania
Cuocolo, Alberto
Perrone-Filardi, Pasquale
author_sort Gargiulo, Paola
collection PubMed
description PURPOSE: Heart failure (HF) is a primary cause of morbidity and mortality worldwide, with significant impact on life quality and extensive healthcare costs. Assessment of myocardial sympathetic innervation function plays a central role in prognosis assessment in HF patients. The aim of this review is to summarize the most recent evidence regarding the clinical applications of iodine-123 metaiodobenzylguanidine ((123)I-MIBG) imaging in patients with HF and related comorbidities. METHODS: A comprehensive literature search was conducted on PubMed and Web of Science databases. Articles describing the impact of (123)I-MIBG imaging on HF and related comorbidities were considered eligible for the review. RESULTS: We collected several data reporting that (123)I-MIBG imaging is a safe and non-invasive tool to evaluate dysfunction of cardiac sympathetic neuronal function and to assess risk stratification in HF patients. HF is frequently associated with comorbidities that may affect cardiac adrenergic innervation. Furthermore, HF is frequently associated with comorbidities and chronic conditions, such as diabetes, obesity, kidney disease and others, that may affect cardiac adrenergic innervation. CONCLUSION: Comorbidities and chronic conditions lead to more severe impairment of sympathetic nervous system in patients with HF, with a negative impact on disease progression and outcome. Cardiac imaging with (123)I-MIBG can be a useful tool to reduce morbidity and prevent adverse events in HF patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00259-022-05941-3.
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spelling pubmed-98521242023-01-21 (123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation Gargiulo, Paola Acampa, Wanda Asile, Gaetano Abbate, Vincenza Nardi, Ermanno Marzano, Federica Assante, Roberta Nappi, Carmela Parlati, Antonio Luca Maria Basile, Christian Dellegrottaglie, Santo Paolillo, Stefania Cuocolo, Alberto Perrone-Filardi, Pasquale Eur J Nucl Med Mol Imaging Review Article PURPOSE: Heart failure (HF) is a primary cause of morbidity and mortality worldwide, with significant impact on life quality and extensive healthcare costs. Assessment of myocardial sympathetic innervation function plays a central role in prognosis assessment in HF patients. The aim of this review is to summarize the most recent evidence regarding the clinical applications of iodine-123 metaiodobenzylguanidine ((123)I-MIBG) imaging in patients with HF and related comorbidities. METHODS: A comprehensive literature search was conducted on PubMed and Web of Science databases. Articles describing the impact of (123)I-MIBG imaging on HF and related comorbidities were considered eligible for the review. RESULTS: We collected several data reporting that (123)I-MIBG imaging is a safe and non-invasive tool to evaluate dysfunction of cardiac sympathetic neuronal function and to assess risk stratification in HF patients. HF is frequently associated with comorbidities that may affect cardiac adrenergic innervation. Furthermore, HF is frequently associated with comorbidities and chronic conditions, such as diabetes, obesity, kidney disease and others, that may affect cardiac adrenergic innervation. CONCLUSION: Comorbidities and chronic conditions lead to more severe impairment of sympathetic nervous system in patients with HF, with a negative impact on disease progression and outcome. Cardiac imaging with (123)I-MIBG can be a useful tool to reduce morbidity and prevent adverse events in HF patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00259-022-05941-3. Springer Berlin Heidelberg 2022-09-08 2023 /pmc/articles/PMC9852124/ /pubmed/36071220 http://dx.doi.org/10.1007/s00259-022-05941-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Gargiulo, Paola
Acampa, Wanda
Asile, Gaetano
Abbate, Vincenza
Nardi, Ermanno
Marzano, Federica
Assante, Roberta
Nappi, Carmela
Parlati, Antonio Luca Maria
Basile, Christian
Dellegrottaglie, Santo
Paolillo, Stefania
Cuocolo, Alberto
Perrone-Filardi, Pasquale
(123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation
title (123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation
title_full (123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation
title_fullStr (123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation
title_full_unstemmed (123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation
title_short (123)I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation
title_sort (123)i-mibg imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852124/
https://www.ncbi.nlm.nih.gov/pubmed/36071220
http://dx.doi.org/10.1007/s00259-022-05941-3
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