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[(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling

PURPOSE: To assess predictive value of (68)Ga-labeled fibroblast activation protein inhibitor-04 ([(68)Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infarction (STEMI). METHODS: Twenty-six patients with STEMI were included in the...

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Autores principales: Zhang, Min, Quan, Weiwei, Zhu, Tianqi, Feng, Shuo, Huang, Xinyun, Meng, Hongping, Du, Run, Zhu, Zhengbin, Qu, Xuezheng, Li, Ping, Cui, Yuke, Shi, Kuangyu, Yan, Xiaoxiang, Zhang, Ruiyan, Li, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852131/
https://www.ncbi.nlm.nih.gov/pubmed/36326870
http://dx.doi.org/10.1007/s00259-022-06015-0
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author Zhang, Min
Quan, Weiwei
Zhu, Tianqi
Feng, Shuo
Huang, Xinyun
Meng, Hongping
Du, Run
Zhu, Zhengbin
Qu, Xuezheng
Li, Ping
Cui, Yuke
Shi, Kuangyu
Yan, Xiaoxiang
Zhang, Ruiyan
Li, Biao
author_facet Zhang, Min
Quan, Weiwei
Zhu, Tianqi
Feng, Shuo
Huang, Xinyun
Meng, Hongping
Du, Run
Zhu, Zhengbin
Qu, Xuezheng
Li, Ping
Cui, Yuke
Shi, Kuangyu
Yan, Xiaoxiang
Zhang, Ruiyan
Li, Biao
author_sort Zhang, Min
collection PubMed
description PURPOSE: To assess predictive value of (68)Ga-labeled fibroblast activation protein inhibitor-04 ([(68)Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infarction (STEMI). METHODS: Twenty-six patients with STEMI were included in the study. [(68)Ga]Ga-DOTA-FAPI-04 PET/MR was performed at baseline and at average 12 months after STEMI. LV remodeling was defined as >10% increase in LV end-systolic volume (LVESV) from baseline to 12 months. RESULTS: The LV remodeling group demonstrated higher [(68)Ga]Ga-DOTA-FAPI-04 uptake volume (UV) at baseline than the non-LV remodeling group (p < 0.001). [(68)Ga]Ga-DOTA-FAPI-04 UV at baseline was a significant predictor (OR = 1.048, p = 0.011) for LV remodeling at 12 months after STEMI. Compared to clinical information, MR imaging and cardiac function parameters at baseline, [(68)Ga]Ga-DOTA-FAPI-04 UV demonstrated better predictive ability (AUC = 0.938, p < 0.001) for late LV remodeling, with sensitivity of 100.0% and specificity of 81.3%. CONCLUSIONS: [(68)Ga]Ga-DOTA-FAPI-04 PET/MR is an effective tool to non-invasively quantify myocardial fibroblasts activation, and baseline [(68)Ga]Ga-DOTA-FAPI-04 UV may have potential predictive value for late LV remodeling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00259-022-06015-0.
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spelling pubmed-98521312023-01-21 [(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling Zhang, Min Quan, Weiwei Zhu, Tianqi Feng, Shuo Huang, Xinyun Meng, Hongping Du, Run Zhu, Zhengbin Qu, Xuezheng Li, Ping Cui, Yuke Shi, Kuangyu Yan, Xiaoxiang Zhang, Ruiyan Li, Biao Eur J Nucl Med Mol Imaging Original Article PURPOSE: To assess predictive value of (68)Ga-labeled fibroblast activation protein inhibitor-04 ([(68)Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infarction (STEMI). METHODS: Twenty-six patients with STEMI were included in the study. [(68)Ga]Ga-DOTA-FAPI-04 PET/MR was performed at baseline and at average 12 months after STEMI. LV remodeling was defined as >10% increase in LV end-systolic volume (LVESV) from baseline to 12 months. RESULTS: The LV remodeling group demonstrated higher [(68)Ga]Ga-DOTA-FAPI-04 uptake volume (UV) at baseline than the non-LV remodeling group (p < 0.001). [(68)Ga]Ga-DOTA-FAPI-04 UV at baseline was a significant predictor (OR = 1.048, p = 0.011) for LV remodeling at 12 months after STEMI. Compared to clinical information, MR imaging and cardiac function parameters at baseline, [(68)Ga]Ga-DOTA-FAPI-04 UV demonstrated better predictive ability (AUC = 0.938, p < 0.001) for late LV remodeling, with sensitivity of 100.0% and specificity of 81.3%. CONCLUSIONS: [(68)Ga]Ga-DOTA-FAPI-04 PET/MR is an effective tool to non-invasively quantify myocardial fibroblasts activation, and baseline [(68)Ga]Ga-DOTA-FAPI-04 UV may have potential predictive value for late LV remodeling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00259-022-06015-0. Springer Berlin Heidelberg 2022-11-03 2023 /pmc/articles/PMC9852131/ /pubmed/36326870 http://dx.doi.org/10.1007/s00259-022-06015-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Zhang, Min
Quan, Weiwei
Zhu, Tianqi
Feng, Shuo
Huang, Xinyun
Meng, Hongping
Du, Run
Zhu, Zhengbin
Qu, Xuezheng
Li, Ping
Cui, Yuke
Shi, Kuangyu
Yan, Xiaoxiang
Zhang, Ruiyan
Li, Biao
[(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
title [(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
title_full [(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
title_fullStr [(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
title_full_unstemmed [(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
title_short [(68)Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
title_sort [(68)ga]ga-dota-fapi-04 pet/mr in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852131/
https://www.ncbi.nlm.nih.gov/pubmed/36326870
http://dx.doi.org/10.1007/s00259-022-06015-0
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