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(18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients

PURPOSE: As bone formation is associated with psoriatic arthritis (PsA), positron emission tomography (PET) using a (18)F-Fluoride tracer may enable sensitive detection of disease activity. Our primary aim was to determine the feasibility of whole-body (18)F-sodium fluoride PET-CT in clinically acti...

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Autores principales: de Jongh, Jerney, Hemke, Robert, Zwezerijnen, Gerben J. C., Yaqub, Maqsood, van der Horst-Bruinsma, Irene E., van de Sande, Marleen G. H., van Kuijk, Arno W. R., Voskuyl, Alexandre E., van der Laken, Conny J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852163/
https://www.ncbi.nlm.nih.gov/pubmed/36370181
http://dx.doi.org/10.1007/s00259-022-06035-w
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author de Jongh, Jerney
Hemke, Robert
Zwezerijnen, Gerben J. C.
Yaqub, Maqsood
van der Horst-Bruinsma, Irene E.
van de Sande, Marleen G. H.
van Kuijk, Arno W. R.
Voskuyl, Alexandre E.
van der Laken, Conny J.
author_facet de Jongh, Jerney
Hemke, Robert
Zwezerijnen, Gerben J. C.
Yaqub, Maqsood
van der Horst-Bruinsma, Irene E.
van de Sande, Marleen G. H.
van Kuijk, Arno W. R.
Voskuyl, Alexandre E.
van der Laken, Conny J.
author_sort de Jongh, Jerney
collection PubMed
description PURPOSE: As bone formation is associated with psoriatic arthritis (PsA), positron emission tomography (PET) using a (18)F-Fluoride tracer may enable sensitive detection of disease activity. Our primary aim was to determine the feasibility of whole-body (18)F-sodium fluoride PET-CT in clinically active PsA patients to depict new bone formation (as a reflection of disease activity) at peripheral joints and entheses. Our secondary aim was to describe (18)F-sodium fluoride findings in the axial skeleton. METHODS: Sixteen patients (female 10/16, age 50.6 ± 8.9 years) with PsA fulfilling CASPAR criteria or with a clinical diagnosis of PsA according to the treating rheumatologist and with ≥ 1 clinically active enthesitis site were included. Of each patient, a whole-body (18)F-sodium fluoride PET-CT scan was performed. All scans were scored for PET-positive lesions at peripheral joints, enthesis sites and the spine. Clinical disease activity was assessed by swollen/tender joint count 44, enthesitis according to MASES and SPARCC scores. RESULTS: Out of 1088 evaluated joints, 109 joints showed PET enhancement, mainly in the interphalangeal and metatarsal joints of the feet (14/109, 12.9%) and the distal interphalangeal joints of the hands (14/109, 12.9%). PET positivity was found at 44/464 enthesis sites, mainly at the patella tendon insertion (11/44, 25%) and quadriceps tendon insertion (10/44, 22.7%). Of the PET-positive joints and enthesis sites, respectively 18.2% and 29.5% were clinically positive; 81.8% and 70.5% of the PET-positive joints and entheses respectively were clinically asymptomatic. In 11 patients, ≥ 1 axial PET-positive lesion was observed, mainly in the cervical spine. CONCLUSIONS: New molecular bone formation was observed on (18)F-sodium fluoride PET-CT scans, in all domains in which PsA disease activity can be observed, with a substantial part showing no clinical symptoms. CLINICAL TRIAL REGISTRATION: EudraCT: 2017-004,850-40, registered on 13 December 2017. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00259-022-06035-w.
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spelling pubmed-98521632023-01-21 (18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients de Jongh, Jerney Hemke, Robert Zwezerijnen, Gerben J. C. Yaqub, Maqsood van der Horst-Bruinsma, Irene E. van de Sande, Marleen G. H. van Kuijk, Arno W. R. Voskuyl, Alexandre E. van der Laken, Conny J. Eur J Nucl Med Mol Imaging Original Article PURPOSE: As bone formation is associated with psoriatic arthritis (PsA), positron emission tomography (PET) using a (18)F-Fluoride tracer may enable sensitive detection of disease activity. Our primary aim was to determine the feasibility of whole-body (18)F-sodium fluoride PET-CT in clinically active PsA patients to depict new bone formation (as a reflection of disease activity) at peripheral joints and entheses. Our secondary aim was to describe (18)F-sodium fluoride findings in the axial skeleton. METHODS: Sixteen patients (female 10/16, age 50.6 ± 8.9 years) with PsA fulfilling CASPAR criteria or with a clinical diagnosis of PsA according to the treating rheumatologist and with ≥ 1 clinically active enthesitis site were included. Of each patient, a whole-body (18)F-sodium fluoride PET-CT scan was performed. All scans were scored for PET-positive lesions at peripheral joints, enthesis sites and the spine. Clinical disease activity was assessed by swollen/tender joint count 44, enthesitis according to MASES and SPARCC scores. RESULTS: Out of 1088 evaluated joints, 109 joints showed PET enhancement, mainly in the interphalangeal and metatarsal joints of the feet (14/109, 12.9%) and the distal interphalangeal joints of the hands (14/109, 12.9%). PET positivity was found at 44/464 enthesis sites, mainly at the patella tendon insertion (11/44, 25%) and quadriceps tendon insertion (10/44, 22.7%). Of the PET-positive joints and enthesis sites, respectively 18.2% and 29.5% were clinically positive; 81.8% and 70.5% of the PET-positive joints and entheses respectively were clinically asymptomatic. In 11 patients, ≥ 1 axial PET-positive lesion was observed, mainly in the cervical spine. CONCLUSIONS: New molecular bone formation was observed on (18)F-sodium fluoride PET-CT scans, in all domains in which PsA disease activity can be observed, with a substantial part showing no clinical symptoms. CLINICAL TRIAL REGISTRATION: EudraCT: 2017-004,850-40, registered on 13 December 2017. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00259-022-06035-w. Springer Berlin Heidelberg 2022-11-12 2023 /pmc/articles/PMC9852163/ /pubmed/36370181 http://dx.doi.org/10.1007/s00259-022-06035-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
de Jongh, Jerney
Hemke, Robert
Zwezerijnen, Gerben J. C.
Yaqub, Maqsood
van der Horst-Bruinsma, Irene E.
van de Sande, Marleen G. H.
van Kuijk, Arno W. R.
Voskuyl, Alexandre E.
van der Laken, Conny J.
(18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients
title (18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients
title_full (18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients
title_fullStr (18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients
title_full_unstemmed (18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients
title_short (18)F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients
title_sort (18)f-sodium fluoride pet-ct visualizes both axial and peripheral new bone formation in psoriatic arthritis patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852163/
https://www.ncbi.nlm.nih.gov/pubmed/36370181
http://dx.doi.org/10.1007/s00259-022-06035-w
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