Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribu...

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Detalles Bibliográficos
Autores principales: Lauerer, Markus, Bussas, Matthias, Pongratz, Viola, Berthele, Achim, Kirschke, Jan S, Wiestler, Benedikt, Zimmer, Claus, Hemmer, Bernhard, Mühlau, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852382/
https://www.ncbi.nlm.nih.gov/pubmed/36427289
http://dx.doi.org/10.1002/acn3.51700
Descripción
Sumario:Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

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