Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribu...

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Autores principales: Lauerer, Markus, Bussas, Matthias, Pongratz, Viola, Berthele, Achim, Kirschke, Jan S, Wiestler, Benedikt, Zimmer, Claus, Hemmer, Bernhard, Mühlau, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852382/
https://www.ncbi.nlm.nih.gov/pubmed/36427289
http://dx.doi.org/10.1002/acn3.51700
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author Lauerer, Markus
Bussas, Matthias
Pongratz, Viola
Berthele, Achim
Kirschke, Jan S
Wiestler, Benedikt
Zimmer, Claus
Hemmer, Bernhard
Mühlau, Mark
author_facet Lauerer, Markus
Bussas, Matthias
Pongratz, Viola
Berthele, Achim
Kirschke, Jan S
Wiestler, Benedikt
Zimmer, Claus
Hemmer, Bernhard
Mühlau, Mark
author_sort Lauerer, Markus
collection PubMed
description Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.
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spelling pubmed-98523822023-01-24 Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume Lauerer, Markus Bussas, Matthias Pongratz, Viola Berthele, Achim Kirschke, Jan S Wiestler, Benedikt Zimmer, Claus Hemmer, Bernhard Mühlau, Mark Ann Clin Transl Neurol Brief Communication Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS. John Wiley and Sons Inc. 2022-11-25 /pmc/articles/PMC9852382/ /pubmed/36427289 http://dx.doi.org/10.1002/acn3.51700 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communication
Lauerer, Markus
Bussas, Matthias
Pongratz, Viola
Berthele, Achim
Kirschke, Jan S
Wiestler, Benedikt
Zimmer, Claus
Hemmer, Bernhard
Mühlau, Mark
Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
title Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
title_full Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
title_fullStr Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
title_full_unstemmed Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
title_short Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
title_sort percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852382/
https://www.ncbi.nlm.nih.gov/pubmed/36427289
http://dx.doi.org/10.1002/acn3.51700
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