Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei

We report the case of a patient with unilateral diffuse frontotemporal epilepsy in whom we implanted a responsive neurostimulation system with leads spanning the anterior and centromedian nucleus of the thalamus. During chronic recording, ictal activity in the centromedian nucleus consistently prece...

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Detalles Bibliográficos
Autores principales: Kundu, Bornali, Arain, Amir, Davis, Tyler, Charlebois, Chantel M., Rolston, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852392/
https://www.ncbi.nlm.nih.gov/pubmed/36480536
http://dx.doi.org/10.1002/acn3.51701
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author Kundu, Bornali
Arain, Amir
Davis, Tyler
Charlebois, Chantel M.
Rolston, John D.
author_facet Kundu, Bornali
Arain, Amir
Davis, Tyler
Charlebois, Chantel M.
Rolston, John D.
author_sort Kundu, Bornali
collection PubMed
description We report the case of a patient with unilateral diffuse frontotemporal epilepsy in whom we implanted a responsive neurostimulation system with leads spanning the anterior and centromedian nucleus of the thalamus. During chronic recording, ictal activity in the centromedian nucleus consistently preceded the anterior nucleus, implying a temporally organized seizure network involving the thalamus. With stimulation, the patient had resolution of focal impaired awareness seizures and secondarily generalized seizures. This report describes chronic recordings of seizure activity from multiple thalamic nuclei within a hemisphere and demonstrates the potential efficacy of closed‐loop neurostimulation of multiple thalamic nuclei to control seizures.
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spelling pubmed-98523922023-01-24 Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei Kundu, Bornali Arain, Amir Davis, Tyler Charlebois, Chantel M. Rolston, John D. Ann Clin Transl Neurol Case Study We report the case of a patient with unilateral diffuse frontotemporal epilepsy in whom we implanted a responsive neurostimulation system with leads spanning the anterior and centromedian nucleus of the thalamus. During chronic recording, ictal activity in the centromedian nucleus consistently preceded the anterior nucleus, implying a temporally organized seizure network involving the thalamus. With stimulation, the patient had resolution of focal impaired awareness seizures and secondarily generalized seizures. This report describes chronic recordings of seizure activity from multiple thalamic nuclei within a hemisphere and demonstrates the potential efficacy of closed‐loop neurostimulation of multiple thalamic nuclei to control seizures. John Wiley and Sons Inc. 2022-12-08 /pmc/articles/PMC9852392/ /pubmed/36480536 http://dx.doi.org/10.1002/acn3.51701 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Study
Kundu, Bornali
Arain, Amir
Davis, Tyler
Charlebois, Chantel M.
Rolston, John D.
Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
title Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
title_full Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
title_fullStr Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
title_full_unstemmed Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
title_short Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
title_sort using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852392/
https://www.ncbi.nlm.nih.gov/pubmed/36480536
http://dx.doi.org/10.1002/acn3.51701
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