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Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer

The early diagnosis of lung cancer is closely associated with the decline of mortality. A panel consisting of seven lung cancer-related autoantibodies (7-AABs) has been shown to be a reliable and specific indicator for the early detection of lung cancer, with a specificity of ~90% and a positive pre...

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Autores principales: Chen, Qing, Zhu, Shaojin, Jiao, Nanlin, Zhang, Ziyu, Gao, Guangjian, Zheng, Wenqiang, Feng, Gang, Han, Wenzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852419/
https://www.ncbi.nlm.nih.gov/pubmed/36741915
http://dx.doi.org/10.3892/etm.2023.11781
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author Chen, Qing
Zhu, Shaojin
Jiao, Nanlin
Zhang, Ziyu
Gao, Guangjian
Zheng, Wenqiang
Feng, Gang
Han, Wenzheng
author_facet Chen, Qing
Zhu, Shaojin
Jiao, Nanlin
Zhang, Ziyu
Gao, Guangjian
Zheng, Wenqiang
Feng, Gang
Han, Wenzheng
author_sort Chen, Qing
collection PubMed
description The early diagnosis of lung cancer is closely associated with the decline of mortality. A panel consisting of seven lung cancer-related autoantibodies (7-AABs) has been shown to be a reliable and specific indicator for the early detection of lung cancer, with a specificity of ~90% and a positive predictive value of ~85%. However, its low sensitivity and negative predictive value limit its wide application. To improve its diagnostic value, the diagnostic efficiencies of 7-AABs in combination with non-specific tumor markers were retrospectively investigated for the detection of early-stage lung cancer. A total of 217 patients with small lung nodules who presented with ground-glass opacity or solid nodules as well as 30 healthy controls were studied. The concentrations of 7-AABs and heat shock protein 90a (HSP90a) were assessed using ELISA. Automated flow fluorescence immune analysis was used for the assessment of CEA, CYFRA21-1, CA199 and CA125 levels. The results showed that 7-AABs + HSP90a possessed a remarkably improved diagnostic efficiency for patients with small pulmonary nodules or for patients with lung nodules of different types, which suggested that 7-AABs in combination with HSP90a could have a high clinical value for the improvement of the diagnostic efficiency of early-stage lung cancer.
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spelling pubmed-98524192023-02-03 Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer Chen, Qing Zhu, Shaojin Jiao, Nanlin Zhang, Ziyu Gao, Guangjian Zheng, Wenqiang Feng, Gang Han, Wenzheng Exp Ther Med Articles The early diagnosis of lung cancer is closely associated with the decline of mortality. A panel consisting of seven lung cancer-related autoantibodies (7-AABs) has been shown to be a reliable and specific indicator for the early detection of lung cancer, with a specificity of ~90% and a positive predictive value of ~85%. However, its low sensitivity and negative predictive value limit its wide application. To improve its diagnostic value, the diagnostic efficiencies of 7-AABs in combination with non-specific tumor markers were retrospectively investigated for the detection of early-stage lung cancer. A total of 217 patients with small lung nodules who presented with ground-glass opacity or solid nodules as well as 30 healthy controls were studied. The concentrations of 7-AABs and heat shock protein 90a (HSP90a) were assessed using ELISA. Automated flow fluorescence immune analysis was used for the assessment of CEA, CYFRA21-1, CA199 and CA125 levels. The results showed that 7-AABs + HSP90a possessed a remarkably improved diagnostic efficiency for patients with small pulmonary nodules or for patients with lung nodules of different types, which suggested that 7-AABs in combination with HSP90a could have a high clinical value for the improvement of the diagnostic efficiency of early-stage lung cancer. D.A. Spandidos 2023-01-03 /pmc/articles/PMC9852419/ /pubmed/36741915 http://dx.doi.org/10.3892/etm.2023.11781 Text en Copyright: © Chen et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Chen, Qing
Zhu, Shaojin
Jiao, Nanlin
Zhang, Ziyu
Gao, Guangjian
Zheng, Wenqiang
Feng, Gang
Han, Wenzheng
Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer
title Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer
title_full Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer
title_fullStr Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer
title_full_unstemmed Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer
title_short Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer
title_sort improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852419/
https://www.ncbi.nlm.nih.gov/pubmed/36741915
http://dx.doi.org/10.3892/etm.2023.11781
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