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Gene-environment correlations and genetic confounding underlying the association between media use and mental health

The increase in online media use and mental health problems have prompted investigations into their association, although most literature is focussed on deleterious effects. We assessed the aetiology of media use and mental health associations (M age = 22.14, SD = 0.85) using twin (n = 4000 pairs) a...

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Autores principales: Ayorech, Ziada, Baldwin, Jessie R., Pingault, Jean-Baptiste, Rimfeld, Kaili, Plomin, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852440/
https://www.ncbi.nlm.nih.gov/pubmed/36658215
http://dx.doi.org/10.1038/s41598-022-25374-0
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author Ayorech, Ziada
Baldwin, Jessie R.
Pingault, Jean-Baptiste
Rimfeld, Kaili
Plomin, Robert
author_facet Ayorech, Ziada
Baldwin, Jessie R.
Pingault, Jean-Baptiste
Rimfeld, Kaili
Plomin, Robert
author_sort Ayorech, Ziada
collection PubMed
description The increase in online media use and mental health problems have prompted investigations into their association, although most literature is focussed on deleterious effects. We assessed the aetiology of media use and mental health associations (M age = 22.14, SD = 0.85) using twin (n = 4000 pairs) and polygenic score methods (n = 6000 unrelated individuals) in the Twins Early Development Study. Beyond the traditionally explored negative uses of online media (online victimisation and problematic internet use), we investigate general media uses such as posting online and watching videos and distinguish both positive (pro-social behaviour) and negative (anxiety, depression, peer and behaviour problems) mental health measures. Negative media use correlated with poor mental health (r = 0.11–0.32), but general media use correlated with prosocial behaviour (r = 0.20) and fewer behavioural problems (r =  − 0.24). Twin analyses showed that both general and negative media use were moderately heritable (ranging from 20 to 49%) and their associations with mental health were primarily due to genetic influences (44–88%). Genetic sensitivity analysis combining polygenic scores with heritability estimates also suggest genetic confounding. Results indicate research on the mental health impact of media use should adopt genetically informed designs to strengthen causal inference.
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spelling pubmed-98524402023-01-21 Gene-environment correlations and genetic confounding underlying the association between media use and mental health Ayorech, Ziada Baldwin, Jessie R. Pingault, Jean-Baptiste Rimfeld, Kaili Plomin, Robert Sci Rep Article The increase in online media use and mental health problems have prompted investigations into their association, although most literature is focussed on deleterious effects. We assessed the aetiology of media use and mental health associations (M age = 22.14, SD = 0.85) using twin (n = 4000 pairs) and polygenic score methods (n = 6000 unrelated individuals) in the Twins Early Development Study. Beyond the traditionally explored negative uses of online media (online victimisation and problematic internet use), we investigate general media uses such as posting online and watching videos and distinguish both positive (pro-social behaviour) and negative (anxiety, depression, peer and behaviour problems) mental health measures. Negative media use correlated with poor mental health (r = 0.11–0.32), but general media use correlated with prosocial behaviour (r = 0.20) and fewer behavioural problems (r =  − 0.24). Twin analyses showed that both general and negative media use were moderately heritable (ranging from 20 to 49%) and their associations with mental health were primarily due to genetic influences (44–88%). Genetic sensitivity analysis combining polygenic scores with heritability estimates also suggest genetic confounding. Results indicate research on the mental health impact of media use should adopt genetically informed designs to strengthen causal inference. Nature Publishing Group UK 2023-01-19 /pmc/articles/PMC9852440/ /pubmed/36658215 http://dx.doi.org/10.1038/s41598-022-25374-0 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ayorech, Ziada
Baldwin, Jessie R.
Pingault, Jean-Baptiste
Rimfeld, Kaili
Plomin, Robert
Gene-environment correlations and genetic confounding underlying the association between media use and mental health
title Gene-environment correlations and genetic confounding underlying the association between media use and mental health
title_full Gene-environment correlations and genetic confounding underlying the association between media use and mental health
title_fullStr Gene-environment correlations and genetic confounding underlying the association between media use and mental health
title_full_unstemmed Gene-environment correlations and genetic confounding underlying the association between media use and mental health
title_short Gene-environment correlations and genetic confounding underlying the association between media use and mental health
title_sort gene-environment correlations and genetic confounding underlying the association between media use and mental health
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852440/
https://www.ncbi.nlm.nih.gov/pubmed/36658215
http://dx.doi.org/10.1038/s41598-022-25374-0
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