Development of a versatile nuclease prime editor with upgraded precision

The applicability of nuclease-based form of prime editor (PEn) has been hindered by its complexed editing outcomes. A chemical inhibitor against DNA-PK, which mediates the nonhomologous end joining (NHEJ) pathway, was recently shown to promote precise insertions by PEn. Nevertheless, the intrinsic i...

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Detalles Bibliográficos
Autores principales: Li, Xiangyang, Zhang, Guiquan, Huang, Shisheng, Liu, Yao, Tang, Jin, Zhong, Mingtian, Wang, Xin, Sun, Wenjun, Yao, Yuan, Ji, Quanjiang, Wang, Xiaolong, Liu, Jianghuai, Zhu, Shiqiang, Huang, Xingxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852468/
https://www.ncbi.nlm.nih.gov/pubmed/36658146
http://dx.doi.org/10.1038/s41467-023-35870-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852468/
https://www.ncbi.nlm.nih.gov/pubmed/36658146
http://dx.doi.org/10.1038/s41467-023-35870-0

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